艾司西酞普兰联合降糖药物对2型糖尿病合并焦虑抑郁患者的疗效

The effect of escitalopram combined with hypoglycemic agent in type 2 diabetes patients with anxiety and depression

目的探讨艾司西酞普兰联合降糖药物对2型糖尿病合并焦虑抑郁患者的效果。方法将2017年1月~2019年1月我院进行治疗的60例2型糖尿病合并焦虑抑郁患者随机对照分组,每组30例。两组患者入院后均接受降糖药物治疗,观察组患者在此基础上加用艾司西酞普兰。比较两组的效果。结果观察组患者焦虑抑郁治疗总有效率显著高于对照组,(P<0.05);观察组患者治疗后空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)水平均显著低于对照组(P<0.05);观察组患者治疗后汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、匹兹堡睡眠质量指数量表(PSQI)评分均显著低于对照组,糖尿病自我效能量表(DMSES)评分、生活质量综合评定问卷(GQOLI-74)评分均显著高于对照组(P<0.05);观察组患者治疗期间低血糖事件发生率显著低于对照组(P<0.05)。结论艾司西酞普兰联合降糖药物更有利于2型糖尿病合并焦虑抑郁患者的血糖控制,还可以改善其心理状态和生活质量。

Objective To explore the effect of escitalopram combined with hypoglycemic agent in type 2 diabetes patients with anxiety and depression.Methods 60 cases of type 2 diabetes patients with anxiety and depression from 2017/01 to 2019/01 were randomly divided into observation group(30 cases)and control group(30 cases).The patients in control group were treated by hypoglycemic agent.The patients in observation group were treated by escitalopram based on the control group.The effect was compared.Results The total effect of anxiety and depression for observation group were higher than the control group(P<0.05).The levels of FPG,2hPG,HbA1c for the observation group after treatment were lower than the control group(P<0.05).The scores of HAMA,HAMD,PSQI for the observation group after treatment were lower than the control group(P<0.05).The scores of DMSES,GQOLI-74 for the observation group after treatment were higher than the control group(P<0.05).The rate of hypoglycemic event for the observation group was lower than that in the control group(P<0.05).Conclusion The escitalopram combined with hypoglycemic agent can improve the blood glucose,psychological states and life quality in type 2 diabetes patients with anxiety and depression.