气体信号分子硫化氢前药开发的研究进展

Recent Advances of Hydrogen Sulfide-Based Therapeutics

硫化氢(H2S)是继一氧化氮(NO)和一氧化碳(CO)之后的第3种内源性气体信号分子,在机体中发挥着重要的生物学效应。研究表明,H2S具有舒张血管、保护心脏、抗炎、抗氧化等生理学作用。把H2S的治疗效果推向临床应用的核心是设计前药将其有效运输到需要部位。从成药性的角度,综述H2S的运输策略和前药开发的研究进展,以期对相关新药的研发与临床治疗提供参考。

Hydrogen sulfide(H2S),together with nitric oxide(NO)and carbon monoxide(CO),belongs to the gasotransmitter family and plays important roles in mammals as a signaling molecule.Many studies have shown the various therapeutic effects of H2S,which include vasodilation,cardioprotection,anti-inflammation and anti-oxidation.One major challenge in the development of H2S-based therapeutics is its delivery.This paper reviews the various recent H2S delivery strategies in the context of eventual developability for guiding future research in the development of H2S-based therapeutics.