迷走神经在急性胆管炎致脓毒症中的作用及其可能机制

The role of vagus nerve in sepsis induced by acute cholangitis and its possible mechanism

急性胆管炎是指由细菌感染所致的胆道系统急性炎症,重症患者符合sepsis 3.0的诊断标准,如不及时救治,死亡率高,是急诊的主要疾病之一。脓毒症的发生和发展依赖于神经、免疫的调节,胆碱能抗炎通路在连接神经和免疫功能中发挥了重要作用。胆道的迷走神经丰富,胆道内压力增高后可引起迷走神经兴奋,以急性胆管炎为基础疾病研究迷走神经在脓毒症中的作用相较于其他感染性疾病更有优势。本文就迷走神经在胆管炎致脓毒症中的可能作用及机制加以阐述。

Acute cholangitis(AC)is a morbid condition with acute inflammation and infection in the bile duct,which meets the diagnostic criteria of sepsis 3.0.AC mortality rate is high without treatment in time,and it is a main disease in emergency department.The occurrence and development of sepsis depend on the regulation of nerve and immunity system,and cholinergic anti-inflammatory pathway plays an important role in connecting nerve and immune function.The biliary tract is innervated by vagus nerves,which can be excited when the pressure increases in the biliary tract.The research on the role of vagus nerves and cholinergic anti-inflammatory pathway(CAIP)in sepsis caused by acute cholangitis is more advantageous than other infectious diseases.