小白菊内酯药理作用的研究进展

Advances in Studies on Pharmacological Effect of Parthenolide

小白菊内酯(parthenolide,PTL)具有抗炎、抗病毒、抗肿瘤等药理作用,同时对白血病和肺纤维化、肝脏疾病等也有一定的疗效。通过综述近年来大量国内外的文献,对PTL的多种药理作用及作用机制做系统的分析,重点阐述PTL对肿瘤细胞的影响,为PTL的进一步研究与临床应用提供理论基础。

Parthenolide shows variety of pharmacological effects,such as anti-inflammatory,anti-viral,and anti-tumor activity.It also has certain curative effect on leukemia,pulmonary fibrosis and liver disease.This paper reviews a large number of domestic and foreign literatures in recent years,systematically analyzes the various pharmacological effects and mechanisms of PTL,and focuses on the impact of PTL on tumor cells,to provide a theoretical basis for further research and clinical application of PTL.