IL-17水平在复发性流产患者血清中的表达及其与抗心磷脂抗体表达的相关性分析

Expression of IL-17 in the Serum of Patients with Recurrent Abortion and its Correlation with the Expression of Anticardiolipin Antibody

【目的】探讨白细胞介素17(IL-17)在复发性流产(RSA)患者中的表达及其与抗心磷脂抗体(ACA)表达的相关性。【方法】选择2016年12月至2017年3月在本院生殖门诊诊治的35岁以下RSA患者46例,其中ACA阳性患者20例(ACA阳性组),ACA阴性患者26例(对照组)。采用ELISA法检测患者血清中IL-17和ACA的表达水平,并分析两者的相关性。【结果】ACA阳性组患者血清IL-17水平为(41.9±5.5)pg/mL,显著高于对照组的(32.1±4.3)pg/mL,其差异有统计学意义(P<0.05)。Pearson相关性分析显示:RSA患者血清IL-17水平与ACA表达呈正相关。【结论】外周血IL-17升高是ACA阳性的RSA患者的免疫异常之一,其可能参与了ACA导致流产的免疫机制。

【Objective】To investigate the expression of interleukin-17(IL-17)in patients with recurrent abortion(RSA)and its correlation with the expression of anticardiolipin antibody(ACA)・【Methods】From December 2016 to March 2017,46 RSA patients under 35 years old were selected for diagnosis and treatment in our reproductive clinic»including 20 ACA positive patients(ACA positive group)and 26 ACA negative patients(control group).The serum levels of IL-17 and ACA were detected by ELISA,and the correlation between them was analyzed.【Results】The serum level of IL-17 in ACA positive group was(41.9±5.5)pg/ml,which was significantly higher than that in the control group(32.1±4.3)pg/mL,the difference was statistically significant(P<0.05).Pearson correlation analysis showed that serum IL-17 level was positively correlated with ACA expression in RSA patients.【Conclusion】The increase of IL-17 in peripheral blood is one of the immune abnormalities in RSA patients with ACA positive,which may be involved in the immune mechanism of ACA induced abortion.