醒脑静注射液联合阿替普酶静脉溶栓治疗对急性脑梗死患者神经功能的影响

Effect of Xingnaojing Injection Combined with Alteplase Intravenous Thrombolytic Therapy on Neurological Function in Patients with Acute Cerebral Infarction

【目的】探讨醒脑静注射液联合阿替普酶静脉涿栓治疗对急性脑梗死患者神经功能的影响。【方法】将90例急性脑梗死患者随机分为两组,对照组患者行阿替普酶涪栓治疗,观察组患者行醒脑等注射液联合阿替普酶静脉溶栓治疗。比较两组治疗前(T1)、治疗1周后(T2)及治疗1个月后(T3)NIHSS得分、简明Fugl-Meyer量表得分、Barthel指数、ESS得分、疗效和不良反应发生情况。【结果】T1时两组患者的各项评分相比较差异均无显著性(P>0.05);T2及两组NIHSS得分均低于上一个时间段的得分(P<0.05),且观察组NIHSS得分低于对照组(P<0.05);T2及T3,两组患者的Fugl-Meyer得分、Barthel指数及ESS得分均高于上一个时间段的得分(P<0.05),且观察组各项指标均高于对照组(P<0.05).察组患者总有效率为95.56%(43/45),高于对照组的80.00%(36/45)(P<0.05).观察组不良反应发生率为8.89%(4/45),显著低于对照组的26.67%(12/45)(P<0.05).【结论】醒脑時注射液联合阿替普酶静脉溶栓治疗急性脑梗死患者疗效较好,可显著改善患者的神经功能,提高患者的自理能力及运动能力,且安全性较高,值得临床推广。

【Objective】To explore the treatment effect of Xingnaojing injection combined with intravenous thrombolysis of atteplase on the neurological function of patients with acute cerebral infarction.【Methods】A total of 90 patients with acute cerebral infarction who admitted to our hospital were randomly divided into the observation group and the control group,with 45 cases in each group.Patients in the control group were only treated with alteplase thrombolytic therapy.While patients in the observation group were treated with Xingnaojing injection combined with alteplase intravenous thrombolytic therapy.Scores of NIHSS,concise Fugl-Meyer scale and ESS,Barthel index,efficacy and adverse events were compared between the two groups before treatment(Ti),1 week after treatment(T2)and 1 month after treatment(T3),respectively.【Results】There were no differences in the scores between the two groups at T1(P>0.05).The scores of NIHSS at T2 and T3 of both groups were lower than those of the previous time point(P<0.05),while the NIHSS scores in the observation group were lower than those in the control group(P<0.05).The scores of the concise fuglmeyer scale,Barthel index and ESS of the two groups at T2 and T3 were higher than those of the previous period(P<0.05);and the above scores in the observation group were higher than those in the control group(P<0.05).The total effective rate of the observation group was 95.56%(43/45),which was higher than that of the control group 80.00%(36/45,P<0.05).The incidence of adverse reactions in the observation group was 8.89%(4/45),which was significantly lower than that in the control group 26.67%(12/45,P<0.05).【Conclusion】The treatment of Xingnaojing injection combined with alteplase intravenous thrombolysis has better therapeutic effects on patients with acute cerebral infarction with less adverse reactions.It greatly improves the neurological function,rehabilitation,self-care ability and exercise capacity of patients,which is worthy of clinical application.