扶正消瘤汤治疗乳腺癌的证候改善及机制分析

Syndromes and Mechanism Analysis of Using Fuzheng Xiaoliu Deoction in Treating Breast Cancer

目的:观察扶正消瘤汤治疗乳腺癌的证候改善及机制状况。方法:选取我院2016年9月至2017年9月外科乳腺癌患者100例,患者采用随机数表法分为研究组(50例)与对照组(50例)。研究组患者术后在常规药物的基础上服用扶正消瘤汤治疗乳腺癌,对照组患者术后在常规药物的基础上服用乳癌术后方治疗乳腺癌,对比分析两组患者的生存质量、中医症候疗效、机体免疫功能及不良反应情况等。结果:患者服药前,两组患者各方面得分情况均无明显差异(P>0.05);患者服药后,两组患者生理状况、情感情况、功能状况、总分等方面得分均高于服药前,差异具有统计学意义(P<0.05);服药后,研究组生理状况、总分等均高于对照组(P<0.05);研究组患者临床有效率为96.00%,明显高于对照组74.00%,具有统计学意义(P<0.05);服药前,两组患者的失眠、口干、恶心呕吐、便秘的中医证候积分无显著性差异(P>0.05);服药后,两组患者的失眠、口干、恶心呕吐、便秘中医证候积分均显著降低,且研究组明显低于对照组(P<0.05);服药后,研究组在CD3^+、CD4^+等方面明显优于对照组,差异具有统计学意义(P<0.05),研究组在CD3^+、CD4^+、CD4^+/CD8^+等方面疗效明显优于服药前,差异具有统计学意义(P<0.05);研究组患者不良反应总发生率为22.00%,明显低于对照组80.00%,具有统计学意义(P<0.05)。结论:扶正消瘤汤能明显改善乳腺癌患者的生存质量、中医症候疗效、机体免疫功能情况,建议在临床中加以推广。

Objective:To observe the improvement of the syndrome of using Fuzheng Xiaoliu Decoction in the treatment of breast cancer and its mechanism analysis. Methods:100 patients with surgical breast cancer from September 2016 to September 2017 in our hospital were selected and randomized into study group(50 cases) and controlled group(50 cases). Patients in the study group were treated with Fuzheng Xiaoliu Decoction on the basis of conventional drugs after operation. The patients in the controlled group were treated with breast cancer after operation on the basis of conventional drugs after operation, and the quality of life was compared between the two groups. TCM syndrome efficacy, immune function and adverse reactions. Results:There were no significant differences in scores of patients in both groups before taking the medicine(P>0.05). After taking the medicine, the scores of physiological status, emotional status, functional status and total score of the two groups were higher than those before taking the medicine(P<0.05). After taking medicine, the physiological status and total score of the study group were higher than that of the controlled group(P<0.05). The clinical effective rate of the study group was 96.00%, which was significantly higher than 74.00% of the controlled group(P<0.05). Before taking the medicine, insomnia, dry mouth, nausea, vomiting and constipation had no significant difference in TCM syndrome scores(P>0.05). After taking the medicine, the insomnia, the score of TCM syndrome of dry, nausea, vomiting and constipation were significantly lower than that of the controlled group(P<0.05), and the scores of CD3^+ and CD4^+ were significantly higher in the study group than those in the control group(P0.05).The curative effect of CD3^+, CD4^+, CD4^+/CD8^+ in the study group was significantly better than that before taking the medicine, the difference was statistically significant(P<0.05). The total incidence of adverse reactions in the study group was 22.00% and in the controlled group was 80.00%, with statistical significance(P<0.05). Conclusion:Fuzheng Xiaoliu Decoction can significantly improve the quality of life of patients with breast cancer, TCM symptoms and immune function, should be clinically promoted.