窄谱中波紫外线治疗白瘢风治疗参数选择

Selection of parameters of narrowband ultraviolet B phototherapy for vitiligo

我国窄谱中波紫外线应用于白瘢风治疗已有十余年,目前,其临床治疗参数尚缺乏统一标准,不规范的治疗不仅不能使患者从中获益,还易引起红斑、水疱、光老化等不良反应。基于世界白瘢风工作组光疗委员会制定的窄谱中波紫外线治疗白瘢风的专家共识,结合相关文献及临床治疗经验,本文从治疗频率、初始治疗剂量、连续治疗或中断治疗后剂量调整、平台期及疗程选择、可接受的最大光疗总次数等方面讨论窄谱中波紫外线治疗参数的选择,提高窄谱中波紫外线治疗白瘢风的疗效。

Narrowband ultraviolet B has been applied to the treatment of vitiligo for more than 10 years in China.Currently,there are no consistent standards for clinical treatment parameters,and patients cannot benefit from non-standard treatment,which is liable to cause erythema,blisters,photoaging and other adverse reactions.Based on the Vitiligo Working Group recommendations for narrowband ultraviolet B phototherapy for vitiligo,relevant literature and clinical experiences,the authors discuss parameters of narrowband ultraviolet B phototherapy for vitiligo from the aspects of treatment frequency,initial dosing,dose adjustment during consecutive treatment or after missed treatment,response plateau,treatment course and maximum acceptable number of phototherapy,so as to improve the efficacy of narrowband ultraviolet B phototherapy for vitiligo.