间充质干细胞及其外泌体与Th17/Treg对银屑病发病机制的研究进展

Role of mesenchymal stem cells and their exosomes in Th17/Treg-related pathogenesis of psoriasis

Th17/Treg细胞失衡是银屑病发病机制中被普遍认可的免疫发病机制之一。间充质干细胞(MSC)可抑制Th17细胞的增殖分化,诱导Treg细胞增殖。MSC分泌的外泌体是MSC进行细胞间信息交流与物质转运的重要载体。研究发现,MSC源性外泌体有与MSC类似的免疫调节作用,可抑制Th17细胞增殖,诱导Treg细胞分化。近年来许多研究表明,银屑病患者骨髓及皮损处皮肤MSC的异常与银屑病的发生有关,但其机制尚不清楚。本文阐述正常MSC及其外泌体对维持Th17/Treg平衡的作用,为研究银屑病患者骨髓及皮损处皮肤MSC异常是如何参与到银屑病的发病提供思路。

T helper 17(Th17)cell/regulatory T(Treg)cell imbalance has been widely considered as one of immunopathogeneses of psoriasis.Mesenchymal stem cells(MSC)can inhibit the proliferation and differentiation of Th17 cells,but induce the proliferation of Treg cells.Exosomes secreted by MSC are a kind of important carrier for intercellular communication and material transportation.Studies have found that exosomes from MSC and MSC have similar immunoregulatory function,which can inhibit the proliferation of Th17 cells and induce the differentiation of Treg cells.In recent years,many studies have shown that abnormalities of MSC in bone marrow and skin lesions of psoriasis patients are related to the occurrence of psoriasis,but the mechanism is still unclear.This review elaborates the role of normal MSC and their exosomes in the maintenance of Th17/Treg balance,which provides ideas for studying how abnormalities of MSC in bone marrow and skin lesions of psoriasis patients participate in the occurrence of psoriasis.