脂肪间充质干细胞免疫调节作用的研究进展

Research progress in immunoregulatory effects of adipose mesenchymal stem cells

脂肪间充质干细胞(adipose derived mesenchymal stromal cell,ADSC)是一种从脂肪组织中分离的多能干细胞,具有来源丰富、取材创伤小以及伦理问题少等特点,在再生医学领域具有良好的应用前景。ADSC具有较强的免疫调节能力,对树突状细胞、巨噬细胞、NK细胞、NKT细胞、B淋巴细胞、T淋巴细胞等多种免疫细胞均具有调节作用。为了更好地了解ADSC在免疫调节方面的作用特点,本文就ADSC对各类免疫细胞的调节作用进行系统综述。

Adipose derived mesenchymal stromal cells(ADSC)are pluripotent stem cells isolated from adipose tissue and have great application potential in regenerative medicine for their rich sources of derivation,relatively less trauma when sampling and few ethical problems.ADSC have preferable immunomodulatory capacity,and can regulate the immunologic functions of dendritic cells,macrophages,NK cells,NKT cells,B lymphocytes and T lymphocytes.In order to better understand the role of ADSC in immunoregulation,this paper systematically reviewed the immunomodulatory effects of ADSC on several representative immune cells.