基于nmsBuilder和OpenSim建立个性化骨肌模型及其验证

Establishment and Verification of Personalized Musculoskeletal Model Based on nmsBuilder and OpenSim

目的 利用nms Builder和Open Sim两款软件构建个性化全膝关节置换(total knee replacement,TKR)术后骨骼肌肉多体动力学模型,并用弹跳式和内推式两种步态对构建模型进行验证分析。方法 利用患者骨骼数据,通过nms Builder建立骨骼实体、骨标点和肌肉标点,从而自动生成对应参考系统和肌肉,将nms Builder生成的骨肌模型导入Open Sim先后执行逆向运动学、静态优化和膝关节接触力分析,最后通过弹跳式和内推式两种步态对模型进行模拟分析,并与实验测量值进行对比验证。结果 除了外侧关节接触力,模型预测的胫股关节接触力幅值和趋势与实验获得数据对比有很好的一致性,构建的骨骼肌肉多体动力学模型可以被用于膝关节研究。结论 利用患者骨骼信息建立的骨肌模型通过输入标记点位置和地面反作用力,可以同时预测出内侧、外侧以及总胫股关节接触力。研究思路可为TKR患者设计个性化膝关节假体提供参考。

Objective To establish a personalized musculoskeletal multi-body dynamics model of total knee replacement(TKR)by two software nmsBuilder and OpenSim,and verify this established model by using bouncy and medthrust gait patterns.Methods Based on skeletal data from a patient,the body,skeletal landmark clouds and muscular landmark clouds were established for automatically generating reference systems and muscles.The musculoskeletal model generated by nmsBuilder was introduced into OpenSim,and inverse kinematics,static optimization and knee joint force analysis were performed successively.Finally,the model was driven by bouncy gait and medthrust gait respectively,and the results were compared with experimental measurements.Results Except for the lateral joint contact forces,the predicted magnitude and trend of knee joint contact forces by the model had a good agreement with the experimental data,and the constructed skeletal muscle multi-body dynamics model could be used for knee joint research.Conclusions The established musculoskeletal multi-body dynamics model could predict the medial,lateral and total tibiofemoral joint contact forces simultaneously by inputting the marker positions and the ground reaction forces.The research ideas of this study can provide references for designing personalized knee prostheses for TKR patient.