基于铁磁流体的亚微米颗粒分离

Separation of sub-micrometer particles based on ferrofluid

微小颗粒的分离在生物、医学、化学及环境等领域具有重要应用。基于微流控技术和铁磁流体的颗粒操控受到广泛关注,但现有研究普遍关注微尺度颗粒,亚微米及纳米尺度颗粒的操控技术仍不成熟。因此,该文旨在研究基于鞘流和负磁泳机制的亚微米颗粒分离。采用数值模拟方法对所设计微通道中铁磁流体中的二元抗磁颗粒分离进行系统研究;考察磁场和流场对颗粒分离的影响,分析规律并阐明力学机制;调节相关参数,实现了微米与微米、亚微米与微米、亚微米与亚微米颗粒的有效分离。该工作可为基于铁磁流体的生物颗粒分离装置的设计和优化提供参考。

The separation of tiny particles has important applications in the fields of biology,medicine,chemistry and the environment.Particle manipulation based on microfluidic technology and magnetic fluid has received extensive attention,but existing research has generally focused on microscale particles.The manipulation techniques of submicron and nanoscale particles are still immature.Therefore,this paper aims to study the separation of submicron particles based on the principles of fluid mechanics and the negative magnetophoresis mechanism.The numerical simulation was used to systematically study the separation of binary diamagnetic particles in ferrofluid in the designed micro channel.The effects of magnetic field and flow field on particle separation were investigated,by which the rules were analyzed and the mechanical mechanism was clarified.Effective separation of micron and micron,submicron and micron,submicron and submicron particles was obtained by adjusting the related parameters.This work can provide guidance for the design and optimization of the devices based on ferrofluid for bioparticle separation.