血清FAR和Hcy评估脑梗死患者颈动脉内膜中层厚度的价值

Value of serum FAR and Hcy in evaluating carotid intima media thickness of patients with cerebral infarction

目的探讨血清纤维蛋白原与白蛋白比值(FAR)和同型半胱氨酸(Hcy)评估脑梗死患者颈动脉内膜中层厚度(CIMT)的价值。方法 459例脑梗死患者分为CIMT增厚组(CIMT≥1.0 mm,250例)和CIMT正常组(CIMT<1.0 mm,209例),检测血常规、Hcy、免疫球蛋白和癌胚抗原(CEA)等相关指标,计算中性粒细胞与淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)、血小板与淋巴细胞比值(PLR)及FAR等,分析影响脑梗死患者CIMT的危险因素。结果与CIMT正常组比较,CIMT增厚组患者年龄大、男性比例高及住院时间长,且NLR、PLR、血沉、CRP、Hcy、CEA及FAR均增高,而LMR和免疫球蛋白M均降低(P<0.05)。年龄、Hcy及FAR为脑梗死患者CIMT增厚的相关影响因素(P<0.05)。结论检测血清FAR及Hcy水平评估脑梗死患者CIMT具有一定临床价值。

Objective To explore the value of serum ratio of fibrinogen to albumin(FAR) and homocysteine(Hcy) detection in evaluating carotid intima media thickness(CIMT) of the patients with cerebral infarction.Methods A total of 459 patients with cerebral infarction was divided into two groups of A(CIMT≥1.0 mm,250 cases) and B(CIMT<1.0 mm,209 cases).The blood routine,Hcy,immune globuline and carcino-embryonic antigen(CEA) were detected.The neutrophil to lymphocyte ratio(NLR),lymphocyte to monocyte ratio(LMR) and platelet to lymphocyte ratio(PLR),and FAR were calculated.The risk factors affecting CIMT were analyzed as well.ResultsCompared with group B,the patients in group A were older in age and had a higher percentage of male,a longer time of hospital stay,the higher levels of NLR,PLR,ESR,CRP,CEA,Hcy and FAR,and the lower levels of LMR and IgM(P<0.05).The age,Hcy and FAR were the influencing factors for CIMT thickening in the patients with cerebral infarction(P<0.05).Conclusion The detection of serum FAR and Hcy has a certain value in assessing CIMT of the patient with cerebral infarction.