纳米碳标记技术用于甲状腺全切术的效果及对患者血清PTH、Ca2+水平的影响

Efficacy of Nano-carbon Labeling Technique in the Total Thyroidectomy and Its Effect on the serum PTH and Ca2+ Levels

目的:探讨纳米碳标记技术用于甲状腺全切术的效果及对患者血清甲状旁腺素(parathyroid hormone,PTH)、钙离子(calcium ion,Ca2+)水平的影响。方法:回顾性分析2017年1月至2018年12月于本院接受甲状腺全切术治疗的120例患者的临床资料,根据术中处理方式不同将其分为观察组和对照组,每组60例。两组患者均实施甲状腺全切术+中央区淋巴结清扫手术,观察组术中使用纳米碳混悬注射液,对照组不使用。比较两组的手术情况、治疗前后血清PTH、Ca2+水平的变化及术后并发症的发生情况。结果:两组术中出血量、术后引流量、甲状旁腺误切率比较差异无统计学意义(P>0.05),观察组手术时间、住院时间比对照组明显缩短(P<0.05);两组手术后1d、3d、7d时血清PTH、Ca2+均明显低于治疗前,且观察组手术后1d、3d、7d时血清PTH、Ca2+均明显高于对照组(P<0.05)。观察组甲状旁腺、喉返神经功能暂时性损伤及低钙血症的发生率均明显低于对照组(P<0.05),两组甲状旁腺、低钙血症、喉返神经功能永久性损伤比较差异无统计学意义(P>0.05)。结论:纳米碳标记技术在甲状腺全切术中效果显著,可有效降低甲状腺误切率,降低甲状旁腺、喉返神经功能暂时性损伤、低钙血症的发生率。

Objective: To study the efficacy of nano-carbon labeling technique in the treatment of total thyroidectomy and its effect on the serum parathyroid hormone(PTH) and calcium ion(Ca2+) levels. Methods: A retrospective analysis of 120 cases of total thyroidectomy in our hospital from January 2017 to December 2018 were divided into the observation group and the control group according to different intraoperative treatment methods, with 60 cases in each group. They were treated with total thyroidectomy and central lymph node dissection were performed, the observation group was treated with nano-carbon suspension injection. The operation conditions, changes of serum PTH, Ca2+ before and after treatment and incidence of complications were compared between the two groups. Results: There was no significant difference in the intraoperative bleeding volume, postoperative drainage volume and parathyroidectomy rate between the two groups(P >0.05);the operation time and hospitalization time in the observation group were significantly shorter than those in the control group(P<0.05);at postoperative 1, 3 and 7 days, the serum PTH and Ca2+ in the two groups were significantly lower than those before treatment, and the serum PTH and Ca2+ in the observation group were significantly higher than those of the control group at postoperative 1, 3 and 7 days(P<0.05);the incidence of parathyroid, recurrent laryngeal nerve function temporary injury and hypocalcemia in the observation group were significantly lower than those in the control group(P<0.05);there was no significant difference in the incidence of parathyroid injury, hypocalcemia and recurrent laryngeal nerve injury between the two groups(P>0.05). Conclusion: Nano-carbon labeling technique is well for total thyroidectomy, which can effectively reduce the misresection rate of thyroid gland, and reduce the incidence of parathyroid, recurrent laryngeal nerve function temporary injury and hypocalcemia.