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无创呼吸机辅助通气在青少年阻塞性睡眠呼吸暂停低通气综合征中的应用效果 被引量:12

Application effect of non-invasive ventilator assisted ventilation in adolescent obstructive sleep apnea hypopnea syndrome
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摘要 目的探讨无创呼吸机辅助通气在青少年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)中的应用效果。方法选取2017年9月~2018年9月我院收治的72例青少年OSAHS患者作为研究对象,按照随机数字表法分为研究组(36例)和对照组(36例),对照组采用常规治疗,研究组采用无创呼吸机辅助通气治疗。比较两组患者睡眠监测情况、炎性因子水平以及睡眠质量。结果两组患者干预前氧减指数(ODI)、呼吸紊乱指数(AHI)、平均血氧饱和度(MSpO2)、最低血氧饱和度(LSpO2)、血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)水平以及匹兹堡睡眠质量指数量表(PSQI)评分比较,差异无统计学意义(P>0.05)。干预后两组ODI、AHI、TNF-α、ET-1、CRP水平、PSQI评分均低于干预前,MSpO2、LSpO2均高于干预前,且研究组ODI、AHI、TNF-α、ET-1、CRP水平、PSQI评分低于对照组,MSpO2、LSpO2高于对照组,差异有统计学意义(P<0.05)。结论无创呼吸机辅助通气治疗青少年OSAHS在改善睡眠监测数据的同时降低机体炎性反应,使患者具有更好的睡眠质量。 Objective To explore the effect of non-invasive ventilator assisted ventilation in adolescent obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 72 patients with adolescent OSAHS admitted to our hospital from September 2017 to September 2018 were enrolled in the study.They were divided into study group(36 cases)and control group(36 cases)according to the random number table method.The control group received routine treatment.The study group was treated with non-invasive ventilator assisted ventilation.The sleep monitoring,inflammatory factor levels,and sleep quality were compared between the two groups.Results There were no significant differences in oxygen index(ODI),respiratory disorder index(AHI),mean oxygen saturation(MSpO2),minimum oxygen saturation(LSpO2),serum C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α),endothelin-1(ET-1)levels,and Pittsburgh sleep quality index(PSQI)scores before intervention(P>0.05).After intervention,the ODI,AHI,and TNF-α,ET-1,CRP levels and PSQI scores were lower than those before the intervention,MSpO2 and LSpO2 were higher than before the intervention in the two groups,and the ODI,AHI,TNF-α,ET-1,CRP levels and PSQI scores of the study group were lower than those of the control group,MSpO2 and LSpO2 were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Non-invasive ventilator assisted ventilation in the treatment of adolescent OSAHS can improve sleep monitoring data while reducing the body′s inflammatory response,so that patients have better sleep quality.
作者 邓杰方 黄穗华 董敬军 DENG Jie-fang;HUANG Sui-hua;DONG Jing-jun(Department of Respiratory Medicine,Bao′an District Central Hospital in Shenzhen City(Shenzhen University Fifth Affiliated Hospital),Guangdong Province,Shenzhen518102,China)
出处 《中国当代医药》 2020年第4期53-55,共3页 China Modern Medicine
关键词 阻塞性睡眠呼吸暂停低通气综合征 无创呼吸机 炎症因子 睡眠质量 Obstructive sleep apnea hypopnea syndrome Noninvasive ventilator Inflammatory factor Sleep quality
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