锌-α2-糖蛋白在白癜风患者血清及皮损组织中的表达

Expression of zinc-α2-glycoprotein in the serum and skin lesion of vitiligo

目的探讨白癜风患者血清、皮损组织锌-α2-糖蛋白(zinc-α2-glycoprotein,ZAG)表达变化及意义。方法白癜风患者26例(白癜风组),同期体检健康者20例(对照组),采用ELISA法检测2组血清ZAG水平;另外选取白癜风患者26例(皮损组),皮肤纤维瘤患者14例(纤维瘤组),分别取皮损组活检组织、纤维瘤组手术切除皮损组织,采用Western blot法检测2组ZAG相对表达量。结果白癜风组血清ZAG水平[(18.90±17.17)μg/L]高于对照组[(10.65±1.54)μg/L](P<0.05);皮损组皮损组织ZAG相对表达量(0.30±0.06)低于纤维瘤组(0.79±0.07)(P<0.05)。结论白癜风患者血清ZAG水平升高,皮损组织ZAG含量降低,ZAG可能参与白癜风的发病。

Objective To investigate the expression and significance of zinc-α2-glycoprotein(ZAG)in the serum and skin lesion of vitiligo.Methods The serum ZAG level was detected by ELISA in 26 patients with vitiligo(vitiligo group)and 20 healthy volunteers(control group).The relative expression of ZAG was detected by Western blot in the biopsy specimen from another 26 patients with vitiligo(lesion group)and 14 patients with cutaneous fibroma(fibroma group)undergoing radical resection of fibroma.Results The serum ZAG level was higher in vitiligo group((18.90±17.17)μg/L)than that in control group((10.65±1.54)μg/L)(P<0.05),and the relative expression of ZAG was lower in lesion group(0.30±0.06)than that in fibroma group(0.79±0.07)(P<0.05).Conclusion ZAG increases in the serum and decreases in the skin lesion of vitiligo,and might be involved in the pathogenesis of vitiligo.