细胞外囊泡及其微RNA在多发性骨髓瘤中的研究进展

Progress of extracellular vesicle and its microRNA in multiple myeloma

多发性骨髓瘤(MM)为血液系统常见疾病,多发于中老年人。MM发病机制尚不明确,目前尚不能完全治愈。近年来的研究发现微RNA(miRNA)在MM发生、发展中起关键作用。此外,MM细胞可释放包含miRNA等信息的细胞外囊泡(EV),参与细胞间信息转导和调控。文章就EV在MM发展中的作用进行综述。

Multiple myeloma(MM)is a common disease in the blood system,which mostly occurs in the middle-aged and the senior people.The pathogenesis of MM is not clear and MM can not be completely cured at present.Recent studies have found that microRNA(miRNA)plays a key role in the occurrence and development of MM.In addition,MM cells can release extracellular vesicle(EV),and involve in the intercellular information transmission and regulation.This paper reviews the role of EV in the development of MM.