不同透析方式对终末期肾脏疾病患者钙磷代谢及炎症状态的影响

Effects of different dialysis methods on calcium and phosphorus metabolism and inflammatory state in patients with end-stage renal disease

目的:从钙磷代谢及炎症状态等方面评估不同透析方式治疗终末期肾脏疾病(ESRD)效果。方法:选取我院72例ESRD患者,简单随机分组,各36例。A组给予腹膜透析,B组给予血液透析。治疗3个月后,统计两组肾功能指标[肌肝(SCr)、尿素氮(BUN)]、血钙、血磷、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平、并发症。结果:与B组比较,治疗3个月后A组SCr、BUN水平较低(P<0.05);与B组比较,治疗3个月后A组血钙、血磷、IL-6、TNF-α水平较低(P<0.05);治疗3个月后,A组并发症发生率为11.11%,低于B组35.56%(P<0.05)。结论:腹膜透析治疗ESRD患者,有助于减少并发症,纠正钙磷代谢紊乱,改善肾功能,且对微炎症状态影响较小。

Objective:To evaluate the effects of different dialysis methods on end-stage renal disease(ESRD)from the aspects of calcium and phosphorus metabolism and inflammation.Methods:72 ESRD patients were randomized into 2 groups with 36 cases in each.Group A was given peritoneal dialysis,while group B recieved hemodialysis.Three months after treatment,the renal function indexes(SCR,BUN),blood calcium,blood phosphorus,interleukin-6(IL-6),tumor necrosis factor-a(TNF)and complications of both groups were counted.Results:Compared with group B,the levels of SCR,BUN,blood calcium,blood phosphorus,IL-6 and TNF-αwere much lower in group A after 3 months*treatment(P<0.05),and the incidence of complications in group A was 11.11%,lower than 35.56%in group B(P<0.05).Conclusion:Peritoneal dialysis can reduce complications,correct the disorder of calcium and phosphorus metabolism,improve renal function of patients,and have less effect on the state of micro inflammation as well.