摘要
生长分化因子15(GDF15)是一种应激反应蛋白,属于转化生长因子β超家族成员之一。GDF15在体内组织广泛表达,如前列腺和胎盘中高表达,肺组织内微量表达。在应激或病理状态下,GDF15表达明显增加。在肺部,GDF15主要由巨噬细胞、血管内皮细胞、肺泡和支气管黏膜上皮细胞分泌。近年来研究表明GDF15与肺部疾病发生及预后密切相关。本文就GDF15在肺部疾病发生中的作用及机制最新研究进行综述。
Growth differentiation factor 15(GDF15)is a stress response protein,which belongs to the super family of transforming growth factor beta.GDF15 is widely expressed in tissues,such as high expression in the prostate and placenta,and weak expression in the lung.The expression of GDF15 is significantly increased in the circumstance of stress or pathology.In the lung,GDF15 is secreted by macrophages,vascular endothelial cells,alveolar and bronchial epithelial cells.Recent studies have shown that GDF15 is closely related to the development and prognosis of lung diseases.This article reviews the latest research on GDF15 in the development of lung diseases.
作者
顾丽娜
王天真
陆菊
曹孟淑
Gu Lina;Wang Tianzhen;Lu Ju;Cao Mengshu(Department of Respiratory and Critical Care Medicine,Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210008,China;Department of Respiratory and Critical Care Medicine,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China)
出处
《国际呼吸杂志》
2020年第1期52-56,共5页
International Journal of Respiration
基金
国家自然科学基金面上项目(81670059)
十三五南京市卫生青年人才培养工程第一层次(QRX17005)。
关键词
生长分化因子
肺疾病
Growth differentiation factor
Lung diseases
