中性粒细胞/淋巴细胞比值在脓毒症中的研究进展

Progress in the study of neutrophil-lymphocyte ratio in sepsis

脓毒症是成人重症监护病房住院和死亡的主要原因之一。临床观察发现当患者病情进展为脓毒症时,耗费大量医疗资源的同时病死率也明显升高。因此,对脓毒症患者进行早期诊断、病情评估、预测预后显得至关重要。目前临床上有较多生物标志物或评分标准,因其各自不同的缺陷,使临床应用受到限制。近年来,国内外许多研究者发现了中性粒细胞/淋巴细胞比值作为一种简便有效的指标与脓毒症患者的病情进展存在着相关性。本综述总结了中性粒细胞/淋巴细胞比值在脓毒症中的研究进展,旨在指导临床医师对脓毒症患者病情有更好的认识,帮助临床医师及时完善诊疗方案,从而降低脓毒症患者的病死率,改善其预后。

Sepsis is one of the leading causes of hospitalization and death in adult intensive care units.Clinical observations have found that when the patient's condition progresses to sepsis,the cost of medical resources is also increased and the mortality rate is also significantly increased.Therefore,early diagnosis,disease assessment,and prognosis of sepsis patients are crucial.At present,there are many biomarkers or scoring standards in clinical practice because of their different defects,which limits the clinical application.In recent years,many researchers at home and abroad have found that neutrophil/lymphocyte ratio as a simple and effective index is related to the progression of patients with sepsis.This review summarizes the research progress of neutrophil/lymphocyte ratio in sepsis,aiming to guide clinicians to have a better understanding of the condition of patients with sepsis,to help clinicians improve the diagnosis and treatment plan in time,thereby reducing the mortality rate of patients with sepsis,to improve its prognosis.