健脾和胃汤辅助治疗冠心病效果及对患者血脂水平影响

Effect of jianpi hewei decoction on coronary heart disease and its effect on blood lipid level

目的中医在治疗冠心病中的作用逐渐受到关注。本研究探讨健脾和胃汤辅助治疗冠心病效果及对患者血脂水平影响。方法选取2017-06-01-2018-07-01洛阳市第一人民医院确诊并接受治疗的冠心病患者作为研究对象,按照性别、年龄和病程组间均衡的原则分为试验组和对照组,每组49例。对照组患者给予西医方案治疗,试验组患者在西医治疗的基础上给予健脾和胃汤治疗。治疗6周后,比较两组疗效、血脂水平及不良反应发生情况。结果试验组治疗总有效率为91.84%,高于对照组的69.39%,χ^2=7.900,P=0.005。治疗后,试验组患者总胆固醇(total cholesterol,TC)水平为(3.22±0.74)mmol/L,低于对照组的(3.99±0.49)mmol/L,t=6.126,P<0.001;甘油三酯(triglyceride,TG)水平为(0.88±0.14)mmol/L,低于对照组的(1.31±0.24)mmol/L,t=10.846,P<0.001;低密度脂蛋白(low-density lipoprotein cholesterol,LDL)水平为(1.66±0.39)mmol/L,低于对照组的(2.30±0.58)mmol/L,t=6.335,P<0.001;高密度脂蛋白(high-density lipoprotein cholesterol,HDL)水平为(2.77±0.66)mmol/L,高于对照组的(2.19±0.36)mmol/L,t=5.370,P<0.001。试验组不良反应发生率为2.04%,低于对照组的12.25%,χ^2=3.846,P=0.049。结论健脾和胃汤辅助治疗冠心病可有效改善患者血脂水平,缓解冠心病症状,且安全性良好。

OBJECTIVE The role of traditional Chinese medicine in the treatment of coronary heart disease has gradually attracted attention.This study investigates the effect of Jianpi Hewei Decoction on chest arthralgia and heart pain(coronary heart disease)and its effect on blood lipid level.METHODS Choose patients with chest palsy and heartache diagnosed and treated in Luoyang First People’s Hospital from June 1,2017 to July 1,2018 as the research object.According to the principle of gender,age and course of disease,they were divided into experimental group and control group,with 49 cases in each group.Patients in the control group were treated with Western medicine,while patients in the experimental group were treated with Jianpi Hewei Decoction on the basis of Western medicine.The curative effect,blood lipid level and adverse reactions of all patients treated with western medicine and integrated traditional Chinese and Western medicine were compared after 6 weeks.RESULTS The total effective rate of the experimental group was 91.84%,which was higher than that of the control group(69.39%,χ^2=7.900,P=0.005).After treatment,the total cholesterol(TC)level of the experimental group was(3.22±0.74)mmol/L,which was lower than that of the control group(3.99±0.49)mmol/L,t=6.126,P<0.001.The level of triglyceride(TG)was(0.88±0.14)mmol/L,which was lower than that of the control group(1.31±0.24)mmol/L,t=10.846,P<0.001;The level of low-density lipoprotein cholesterol(LDL)was(1.66±0.39)mmol/L,which was lower than that of the control group(2.30±0.58)mmol/L,t=6.335,P<0.001.The high-density lipoprotein cholesterol(HDL)level was(2.77±0.66)mmol/L,which was higher than that of the control group(2.19±0.36)mmol/L,t=5.370,P<0.001.The incidence of adverse reactions in the experimental group was 2.04%,which was lower than that of the control group(12.25%,χ^2=3.846,P=0.049).CONCLUSION The use of Jianpi Hewei Decoction in the adjuvant treatment of chest arthralgia and heartache can effectively improve the blood lipid level,alleviate the symptoms of chest arthralgia and heartache,and has good safety.