原发性高血压患者单核细胞趋化蛋白-1基因多态性对尼索地平疗效的影响

Effect of monocyte chemoattractant protein-1 gene polymorphism on the efficacy of nisoldipine in patients with essential hypertension

目的探究并分析原发性高血压(高血压)患者单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)基因多态性与尼索地平疗效及血清整合素β3、血清细胞间黏附分子(serum intercellular adhesion molecule,sICAM)-1浓度的相关性。方法选取2017年3月至2018年3月成都市温江区人民医院收治的高血压患者100例(基因型为-2076A/T或者-2518G/A),根据患者基因检测结果分为观察组(基因型-2076A/T)及对照组(基因型-2518G/A)。两组患者均给予尼索地平治疗,观察并记录两组患者治疗前,治疗后1个月,治疗后3个月血压控制情况以及血清整合素β3、sICAM-1浓度。结果两组患者性别、年龄、体质量、病程、用药等比较,差异无统计学意义(P>0.05)。治疗后两组患者血压、整合素β3浓度、sICAM-1浓度均较治疗前明显降低,差异有统计学意义(P<0.05),但观察组患者血压、整合素β3浓度、sICAM-1浓度降低程度显著高于对照组,差异有统计学意义(P<0.05)。观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论采用尼索地平治疗后,MCP-1基因型为-2076A/T的高血压患者的疗效及血清整合素β3、sICAM-1浓度降低程度显著高于MCP-1基因型为-2518G/A的高血压患者。

Objectives To explore and analyze the relationships between human monocyte chemoattractant protein-1(MCP-1)gene polymorphism and the efficacy of nisoldipine,serum concentrations of integrin beta 3 and intercellular adhesion molecule(sICAM)-1 in patients with essential hypertension.Methods A total of 100 patients with essential hypertension(genotype-2076A/T or-2518G/A)were selected from March 2017 to March 2018 in Chengdu Wenjiang District People′s Hospital.According to the results of gene test,the patients were divided into observation group(geno⁃type-2076A/T)and control group(genotype-2518G/A).Both groups were treated with nisoldipine.Blood pressure con⁃trol and serum concentrations of integrin beta 3 and sICAM-1 were observed and recorded before treatment,1 month after treatment and 3 months after treatment.Results There were no significant differences in sex,age,body mass,course of disease and medication between the two groups(P>0.05).After treatment,blood pressures,serum concentrations of integrin beta-3,sICAM-1 of the two groups were significantly lower than those before treatment(P<0.05),but the decreasing degree of blood pressures,serum concentrations of integrin beta-3,sICAM-1 in observation group were significantly higher than those of control group(P<0.05).Total effective rate of observation group was significantly higher than that of control group(P<0.05).Conclusions Curative effect and decreasing degree of serum concentrations of integrin beta 3 and sICAM-1 of patients with MCP-1 genotype-2076A/T are significantly higher than those of patients with MCP-1 genotype-2518G/A after treatment of nisoldipine for essential hypertension.