血小板计数和血小板平均体积及血小板与淋巴细胞计数比值对未足月胎膜早破的预测价值分析

An analysis of the predictive value of mean platelet volume and ratio of platelet to lymphocyte count for premature rupture of membranes before term

目的探讨血小板计数(PLT)、血小板平均体积(MPV)、血小板计数与淋巴细胞计数比值(PLR)预测未足月胎膜早破的应用价值。方法回顾性分析2018年6月至2019年1月本院收治的58例未足月胎膜早破孕妇(观察组)和同期收治的57名足月正常孕妇(对照组)的临床病理资料。结果观察组PLT、MPV、PLR与对照组比较差异均具有统计学意义(P<0.001);观察组中绒毛膜羊膜炎患者的PLT、PLR显著高于非绒毛膜羊膜炎患者,MPV低于非绒毛膜羊膜炎患者(P<0.001);观察组中绒毛膜羊膜炎患者发病时的MPV显著低于发病前,PLR和PLT显著高于发病前(P<0.01);不同指标预测绒毛膜羊膜炎所致胎膜早破的敏感性、特异性、准确性、漏诊率和误诊率依次为PLT:51.72%、96.49%、76.52%、48.28%、3.51%,PLR:65.52%、77.19%、75.83%、34.48%、22.81%,MPV:72.41%、70.18%、74.34%、27.59%、29.82%。结论孕妇血清PLT、PLR与MPV水平对于绒毛膜羊膜炎导致未足月胎膜早破具有一定的预测价值和临床实践意义。

Objective To investigate the application value of platelet count(PLT), mean platelet volume(MPV), platelet count and lymphocyte count ratio(PLR) in predicting premature rupture of membranes. Methods A retrospective analysis of 58 cases of premature rupture of membranes in pregnant women(observation group) from June 2018 to January 2019 and the clinical and pathological data of 57 normal pregnant women(control group). Results The PLT, MPV and PLR of the observation group were significantly different from the control group(P<0.001). The PLT and PLR of the patients with chorioamnionitis in the observation group were significantly higher than those of the non-chorioamnionitis patients, and the MPV was lower than the non-vuff. Patients with membranous amniocentesis(P<0.001). MPV in the observation group was significantly lower than that before the onset, PLR and PLT were significantly higher than before the onset(P<0.01). The sensitivity, specificity, accuracy, missed diagnosis rate and misdiagnosis rate of premature rupture of membranes caused by chorionic amnitis predicted by different indexes were as follows PLT:51.72%, 96.49%, 76.52%, 48.28%, 3.51%, PLR: 65.52%, 77.19%, 75.83%, 34.48%, 22.81%, MPV: 72.41%, 70.18%, 74.34%, 27.59%, 29.82%.Conclusion Serum PLT, PLR and MPV levels in pregnant women have certain predictive value and clinical practical significance for chorioamnionitis leading to premature rupture of membranes.