慢性肾衰竭合并神经病变患者治疗中联用高通量血液透析与左卡尼汀的临床分析

Clinical analysis of high-throughput hemodialysis combined with levocarnitine in the treatment of chronic renal failure with neuropathy patients

目的探讨慢性肾衰竭合并神经病变患者治疗中联用高通量血液透析与左卡尼汀的临床效果。方法选取2018年1月至2019年1月收治的慢性肾衰竭合并神经病变患者60例,按照随机数字表法分为对照组和观察组,各30例。对照组行常规血液透析治疗,观察组行高通量血液透析联合左卡尼汀治疗,比较两组临床疗效。结果观察组治疗总有效率为93.33%,高于对照组的70.00%,差异具有统计学意义(P<0.05);两组治疗后胫神经、腓总神经及正中神经的感觉神经传导速度均高于治疗前,且观察组胫神经、腓总神经及正中神经的感觉神经传导速度高于对照组,差异具有统计学意义(P<0.05);两组治疗过程中并未出现严重不良反应。结论慢性肾衰竭合并神经病变患者治疗中联用高通量血液透析与左卡尼汀的效果显著,可有效改善患者周围神经病变,且安全性较高。

Objective To investigate the clinical effect of high-throughput hemodialysis combined with levocarnitine in the treatment of chronic renal failure with neuropathy patients. Methods 60 patients with chronic renal failure with neuropathy from January 2018 to January 2019 were randomly divided into the control group and the observation group, with 30 cases in each group. The control group was treated with routine hemodialysis, the observation group was treated with high-flux hemodialysis combined with levocarnitine, the clinical effect was compared between the two groups. Results The total effective rate in the observation group was 93.33%, which was significantly higher than the control group(70.00%), the difference was statistically significant(P<0.05). And the sensory conduction velocity of nervi tibialis, nervus peroneus communis, nervi medianus after treatment in the two groups were significantly difference(P<0.05). And the sensory nerve conduction velocity of nervi tibialis, nervus peroneus communis, nervi medianus in the observed group were higher than the control group, the difference was statistically significan(P<0.05). There were no serious adverse reactions during treatment in both groups. Conclusion High-flux hemodialysis combined with levocarnitine is effective in the treatment of Chronic Renal Failure with neuropathy, which can improve the peripheral neuropathy effectively and has high safety.