穿孔修补术联合泮托拉唑治疗十二指肠溃疡穿孔的临床效果评估

Clinical evaluation of perforation repair combined with pantoprazole in the treatment of perforated duodenal ulcer

目的观察穿孔修补术联合泮托拉唑治疗十二指肠溃疡穿孔患者的临床疗效及安全性,为十二指肠溃疡穿孔患者的治疗提供参考。方法选取2013年10月至2018年10月在本院行手术治疗的60例十二指肠溃疡穿孔患者作为研究对象,按照手术顺序编号,单号设为对照组,双号设为观察组,各30例。对照组进行穿孔修补术治疗,观察组采用穿孔修补术联合泮托拉唑钠肠溶片治疗。两组患者均观察随访至术后6个月。比较两组患者术后康复指标(下床活动时间、溃疡面愈合时间、术后6个月溃疡面愈合质量、术后住院治疗时间),术后6个月内并发症率及再次手术率。结果观察组患者术后下床活动时间、溃疡面愈合时间及住院时间均短于对照组(P<0.05);术后6个月,观察组患者溃疡面高质量愈合率明显高于对照组患者,溃疡复发率、再次手术率均明显低于对照组患者(P<0.05);观察组患者恶心呕吐、嗳气、腹痛腹胀症状消失时间均短于对照组患者(P<0.05);术后6个月内观察组患者并发症发生率低于对照组患者(P<0.05)。结论穿孔修补术联合泮托拉唑治疗十二指肠溃疡穿孔可有效缩短患者术后康复时间,提高溃疡愈合质量,降低并发症发生率及溃疡复发率,是治疗十二指肠溃疡穿孔的理想方案。

Objective To observe the clinical efficacy and safety of perforation repair combined with pantoprazole in the treatment of patients with perforated duodenal ulcer. Methods 60 patients with perforated duodenal ulcer who had received surgical treatment in our hospital from October 2013 to October 2018 were selected as the study subjects. The Numbers were numbered according to the operation sequence. The single number was set as the control group, and the double number was set as the observation group, with 30 cases each in each group. The control group received perforation repair,while the observation group received perforation repair combined with pantoprazole sodium enteric-coated tablets. Patients in both groups were observed and followed up for 6 months after surgery. Postoperative rehabilitation indicators(time of getting out of bed, healing time of ulcer surface, healing quality of ulcer surface 6 months after surgery, and postoperative hospitalization time), complication rate and reoperation rate were compared between the two groups. Results The activity time, healing time and hospitalization time of the observation group were shorter than those of the control group(P<0.05).6 months after the operation, the rate of high-quality ulcer healing in the observation group was significantly higher than that in the control group, and the rate of ulcer recurrence and re-operation was significantly lower than that in the control group(P<0.05). The disappearance time of nausea, vomiting,belching, abdominal pain and abdominal distension in the observation group was shorter than that in the control group(P<0.05). The incidence of complications in the observation group was lower than that in the control group(P<0.05). Conclusion Perforation repair combined with pantoprazole for the treatment of duodenal ulcer perforation can effectively shorten the postoperative recovery time of patients, improve the quality of ulcer healing,reduce the incidence of complications and ulcer recurrence rate, it is an ideal plan for the treatment of duodenal ulcer perforation.