氯氮平联合重复经颅磁刺激对难治性精神分裂症临床症状及认知功能的影响

Effect of clozapine combined with repetitive transcranial magnetic stimulation on clinical symptoms and cognitive function in patients with refractory schizophrenia

目的探讨氯氮平联合重复经颅磁刺激对难治性精神分裂症临床症状及认知功能的影响。方法选取2017年1月至2019年1月本院收治的难治性精神分裂症患者60例,根据随机数表法分为对照组与观察组,各30例。对照组采用氯氮平治疗,观察组采用氯氮平联合重复经颅磁刺激治疗,对比两组临床症状、认知功能及不良反应。结果与对照组比较,观察组患者PANSS中各分量表评分均较低,MoCA评分较高,差异有统计学意义(P<0.05);两组患者不良反应总发生率比较,差异无统计学意义。结论对难治性精神分裂症患者采用氯氮平联合重复经颅磁刺激,不仅可减轻临床症状,还利于改善患者认知功能。

Objective To investigate the effect of clozapine combined with repetitive transcranial magnetic stimulation on clinical symptoms and cognitive function in patients with refractory schizophrenia. Methods 60 patients with refractory schizophrenia in the hospital from January 2017 to January 2019 were selected, and they were divided into the control group and the observation group by random number table method, with 30 cases in each group. The control group was given clozapine, while the observation group was treated with clozapine and repetitive transcranial magnetic stimulation. The clinical symptoms, cognitive function and adverse reactions were compared between the two groups. Results Compared with control group, the scores of PANSS in observation group were lower, while the score of MoCA in observation group was higher(P<0.05). There was no statistical difference in the total incidence of adverse reactions between the two groups. Conclusion Clozapine combined with repetitive transcranial magnetic stimulation in treatment of patients with refractory schizophrenia can reduce clinical symptoms and improve cognitive function.