血清cTnⅠ、hs-CRP、D-二聚体和尿酸检测对早期诊断老年急性心肌梗死的应用价值

Detection of serum cTnI, hs-CRP, D-Dimer and uric acid and their application value in early diagnosis of acute myocardial infarction in the elderly

目的探讨联合检测血清肌钙蛋白Ⅰ(cTnⅠ)、超敏C-反应蛋白(hs-CRP)、D-二聚体(D-D)和尿酸(UA)在老年急性心肌梗死(AMI)早期诊断中的临床应用价值。方法择某选院心内科住院确诊为AMI的92例老年患者为观察组,选取同一时期体检的84例老年健康者为对照组。检测两组血清cTnⅠ、hs-CRP、D-D和UA水平,统计4项指标联合检测对诊断AMI的敏感性和特异性。结果观察组cTnⅠ、hs-CRP、D-D及UA水平均显著高于对照组,差异有统计学意义(P<0.01);4项联合诊断的敏感性(94.6%)、特异性(96.9%)均明显高于各指标的单项检测。结论cTnⅠ、hs-CRP、DD和UA联合检测可以显著提高老年AMI诊断的敏感性和特异性,对老年AMI的早期诊断具有较高的临床价值。

Objective To investigate the combined detection of serum cardiac troponin Ⅰ(cTnⅠ),high-sensitivity Creactive protein(hs-CRP),D-dimer(DD)and uric acid(UA)and their value in early diagnosis of acute myocardial infarction(AMI)in the elderly.Methods 92 elderly patients diagnosed with AMI in the Department of Cardiology of a hospital were selected as the Observation Group and 84 healthy elderly volunteers receiving physical examination during the same period were selected as the Control Group.The blood serum cTnⅠ,hs-CRP,DD and UA level of the two groups were detected.The AMI sensitivity and specificity of the combined detection of the four markers was statistically analyzed.Results The Observation Group had the cTnⅠ,hs-CRP,DD and UA level significantly higher than the Control Group,and the differences were statistically significant(P<0.01).The sensitivity(94.6%)and specificity(96.9%)of the combined detection of the four markers were significantly higher than the single detection of each marker.Conclusion The combined detection of cTnⅠ,hs-CRP,D-D and UA can significantly improve the sensitivity and specificity of AMI diagnosis in the elderly and has a high clinical value in the early diagnosis of AMI in the elderly.