窄谱中波紫外线联合咪唑斯汀治疗慢性自发性荨麻疹的疗效观察

Efficacy of narrow-band UVB combined with mizolastine in the treatment of chronic spontaneous urticaria

目的观察窄谱中波紫外线联合咪唑斯汀治疗慢性自发性荨麻疹的疗效。方法127例患者随机分为治疗组(65例)和对照组(62例),两组患者均口服咪唑斯汀片,治疗组在此基础上联合窄谱中波紫外线(NB-UVB)光疗,治疗4周。观察两组治疗前与治疗第2、4周的症状总积分及药物不良反应,比较两组治疗第2、4周的疗效。结果治疗第2、4周,两组患者的症状总积分均较治疗前下降,且以治疗组更为显著(P<0.01)。治疗第2、4周时治疗组的疗效均优于对照组(P<0.01)。结论谱中窄波紫外线联合咪唑斯汀治疗慢性自发性荨麻疹疗效显著、安全,值得临床推广。

Objective To observe the effect of narrow-band UVB combined with mizolastine in the treatment of chronic spontaneous urticaria.One hundred and twenty-seven patients with chronic spontaneous urticaria were randomly divided into 2 groups,the Therapy Group(65 cases)and the Control Group(62 cases).Both groups were orally administered with mizolastine tablets,and the Therapy Group was additionally treated with narrow-band UVB phototherapy for 4 weeks.The total clinic symptomatic score and adverse drug reactions of the two groups before the treatment and 2 and 4 weeks after the treatment were observed.The efficacy at 2 and 4 weeks after the treatment was compared between the two groups.Results At 2 and 4 weeks after the treatment,the symptomatic scores of urticaria in the two groups were significantly reduced,and the Therapy Group showed a more significant reduction(P<0.01).The Therapy Group had the efficacy superior to the Control Group at 2 and 4 weeks after the treatment(P<0.01).Conclusion Narrow-band UVB combined with mizolastine has significant efficacy and is safe,which is worth clinical promotion.