美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的效果比较

Comparison of Mesalazine and Sulfasalazine in Treating Ulcerative Colitis

目的比较美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎的临床效果。方法选取2018年2月~2019年2月在我院诊治的70例溃疡性结肠炎患者为研究对象,采用随机数字表法分为对照组和观察组,各35例。对照组采用柳氮磺吡啶治疗,观察组采用美沙拉嗪治疗,比较两组临床治疗总有效率、临床症状(腹泻、腹痛、黏液便血)积分、结肠镜检评分、C反应蛋白水平及不良反应(恶心呕吐、粒细胞减少、头痛、外周血白细胞下降)发生情况。结果观察组临床治疗总有效率为94.28%,高于对照组的82.85%,差异有统计学意义(P<0.05);治疗后两组腹泻、腹痛、黏液便血积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后两组结肠镜检评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后两组C反应蛋白水平均低是否于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为8.57%,低于对照组的22.85%,差异有统计学意义(P<0.05)。结论美沙拉嗪治疗溃疡性结肠炎的临床效果优于柳氮磺吡啶,有助于炎症吸收,改善临床症状,且不良反应少,值得临床应用。

Objective To compare the clinical effects of mesalazine and sulfasalazine in the treatment of ulcerative colitis.Methods A total of 70 patients with ulcerative colitis diagnosed and treated in our hospital from February 2018 to February 2019 were selected as the research subjects.They were divided into the control group and the observation group by random number table method,35 cases in each group.The control group was treated with sulfasalazine and the observation group was treated with mesalazine.The total effective rate,clinical symptoms(diarrhea,abdominal pain,mucus and blood in the stool)score,colonoscopy score,C-reactive protein level,and adverse reactions were compared between the two groups(Nausea and vomiting,granulocytopenia,headache,peripheral white blood cell decline).Results The total effective rate of clinical treatment in the observation group was 94.28%,which was higher than 82.85%in the control group,the difference was statistically significant(P<0.05).After treatment,the scores of diarrhea,abdominal pain,and mucus in the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).The colonoscopy scores of the two groups were lower than before treatment and the observation group was lower than the control group,the difference was statistically significant(P<0.05);The C-reactive protein level in the two groups after treatment was lower than before the treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 8.57%,lower than 22.85%in the control group,the difference was statistically significant(P<0.05).Conclusion Mesalazine is superior to sulfasalazine in the treatment of ulcerative colitis,which is helpful for inflammation absorption,improves clinical symptoms,and has fewer adverse reactions,which is worthy of clinical application.