肠道菌群：功能性胃肠病的防治新靶点

Gut microbiota:a new target for prevention and treatment of FGIDs

功能性胃肠病(FGIDs)是一组无器质性改变但存在消化功能异常的疾病,是消化科门诊中常见疾病之一。在最新的罗马Ⅳ标准中将功能性肠胃病定义为脑-肠互动异常疾病。肠道菌群在脑-肠互动中发挥重要作用,参与功能性胃肠病发生的多种病理生理机制。肠道菌群失调主要通过增加肠道渗透及内脏高敏感性、改变肠道动力和激活免疫反应参与FGIDs症状产生。因此,重塑肠道菌群稳态的策略在治疗FGIDs中显示出一定的前景。

Functional gastrointestinal disorders are a group of diseases without organic changes but with abnormal digestive function.They are common diseases in digestive clinics.In the up-to-date Rome IV criteria,FGIDs are defined as disorders of gut-brain interactions.Gut microbiota plays an important role in gut-brain interactions and participates in various pathophysiological mechanisms of FGIDs.Dysbiosis of gut microbiota is mainly involved in FGIDs symptoms by increasing intestinal permeability and visceral hypersensitivity,altering intestinal motility and activating immune response.Therefore,the strategy of remodeling intestinal microbiota homeostasis has shown some prospects in the treatment of FGIDs.