MicroRNA影响椎间盘退变过程的研究进展及可发展空间

Research progress and development space of microRNA in the process of intervertebral disc degeneration

背景:在细胞与分子水平上明确MicroRNA(miRNA)在椎间盘退变过程的作用机制,可为早预防或治疗椎间盘退变继发的一系列脊柱疾患提供新的思路。目的:综述miRNA在椎间盘退变原因和机制中的研究现状。方法:应用计算机检索PubMed数据库、万方数据库和中国知网数据库,英文检索词为“miRNA、Intervertebral disc degeneration、Extracellular matrix、Apoptosis、Autophagy、Cartilage endplate、Nucleus pulposus、Fibrous ring”,中文检索词为“miRNA、椎间盘退变、细胞外基质、凋亡、自噬、软骨终板、髓核、纤维环”,最终纳入58篇文章进行综述。结果与结论:miRNA在椎间盘退变过程中的作用已被广泛研究,部分具体机制得到验证;研究多局限于髓核组织,对软骨终板及纤维环报道较少;随着miRNA深入研究,临床方面的研究仍有较大发展空间。

BACKGROUND:Full-understanding of the mechanism of microRNA(miRNA)in the process of intervertebral disc degeneration at the cellular and molecular levels can provides new idea for the early prevention or treatment of a series of spinal diseases to intervertebral disc degeneration.OBJECTIVE:To summarize the research status of the role of miRNA in the cause and mechanism of intervertebral disc degeneration.METHODS:A computed-based online retrieval of PubMed,Wanfang and CNKI databases was conducted with the keywords of“miRNA,intervertebral disc degeneration,extracellular matrix,apoptosis,autophagy,cartilage endplate,nucleus pulposus,fibrous ring”in English and Chinese,respectively.Finally 58 eligible articles were included for review.RESULTS AND CONCLUSION:The role of miRNA in intervertebral disc degeneration has been widely studied,and some of the specific mechanisms have been verified.Most of the studies are limited to the nucleus pulposus,and there are few reports on cartilage endplate and annulus fibrosus.With the in-depth study of miRNA,there is still much space for clinical research.