细胞自噬在骨肉瘤中的作用机制

Mechanism of autophagy in osteosarcoma

背景:自噬似乎在癌症形成的早期阶段充当肿瘤抑制因子,然而在后期阶段,自噬可能支持或促进肿瘤生长、扩散,并可能增加治疗耐药性。目的:综述国内外相关文献,总结自噬与骨肉瘤的关系,探讨细胞自噬在骨肉瘤中的作用机制及治疗前景。方法:中文以“自噬,化学治疗,自噬相关因子,骨肉瘤,细胞凋亡,耐药”检索CNKI、万方、维普数据库;英文以“Autophagy,Chemotherapy,Autophagy related factors,Osteosarcoma,Apoptosis,Drug resistance”检索PubMed数据库,收录与自噬在骨肿瘤中的作用机制相关的文献报道,按照选文标准对文献进行筛选,并排除重复性研究及年代久远的文献。共纳入52篇文章进行综述分析。结果与结论:①自噬可能是促进和预防癌症的重要因素,其作用随着肿瘤发生发展而表现出不同;②对自噬途径的充分了解和调节可能提高肿瘤治疗的潜力;③考虑到自噬在肿瘤生物学中的重要性,研究自噬调节miRNA将有助于更好地了解恶性肿瘤,并可能会发现新的疾病标志物和治疗策略;④上述结论仍需要大量更科学的研究及合理的实验予以证实。

BACKGROUND:Autophagy may be a tumor-inhibiting factor at the early stage of carcinogenesis,while at late stage,it may support or promote the tumor growth and spread,and may contribute to drug resistance.OBJECTIVE:To review the related literature at home and abroad,summarize the relationship between autophagy and osteosarcoma,and explore the mechanism of autophagy in osteosarcoma and its therapeutic prospect.METHODS:CNKI,Wanfang,VIP and PubMed databases were retrieved with the keywords of“autophagy,chemotherapy,autophagy related factors,osteosarcoma,apoptosis,drug resistance”in Chinese and English,respectively.The articles related to the mechanism of autophagy in bone tumors were included.The literature was screened according to the selection criteria,and the repetitive and the long-standing literature were excluded.Fifty-two articles were included for review and analysis.RESULTS AND CONCLUSION:(1)Autophagy may be an important factor in promoting and preventing cancer,and its effect varies with the occurrence of development of tumor.(2)The full understanding and regulation of autophagy pathway can significantly improve the potential of tumor therapy.(3)Considering the importance of autophagy in tumor biology,research on autophagy-regulated miRNA will help us to better understand malignant tumors and may discover new disease markers and treatment strategies.(4)The above conclusion still needs a lot of scientific research and reasonable experiments to confirm.