ACE抑制肽的研究进展

Research progress of ACE inhibiting peptide

随着高血压患者的大幅增加和人们对健康的重视,血管紧张素转换酶(ACE)抑制肽作为有效的降血压多肽,又因无毒副作用,使其成为近些年的研究热点。文章综述了ACE抑制肽的作用机理和研究历史,从植物及动物方面介绍了多肽的来源,并阐述了直接酶解法、发酵法、固相合成法制备ACE抑制肽方法,以及从体外活性检测和体内活性检测介绍ACE抑制肽检测方法,希望为ACE抑制肽的深入研究提供依据。

With the dramatic increase in the number of patients with hypertension and people's attention to health,angiotensin-I converting enzyme(ACE)inhibitory peptides have become an effective blood pressure lowering peptide due to its non-toxic side effect and it has become a research hotspot in recent years.In this paper,the mechanism and research history of ACE inhibitory peptides were reviewed.The source of the peptides were introduced from the aspects of plant and animal,and the direct enzymatic hydrolysis,fermentation,solid phase synthesis for the preparation of ACE inhibitory peptides were expounded,and in vitro and in vivo ACE inhibitory peptides activity detection method was introduced,in order to provide the basis for further study of the ACE inhibitory peptides.