胆道恶性肿瘤临床研究进展与展望

Progress and prospect of clinical research on biliary tract cancers

胆道恶性肿瘤(BTC)包括胆囊癌及来源于胆管上皮细胞的胆管癌,具有早期诊断困难、进展迅速、解剖部位复杂等特点。手术是BTC的主要治疗手段,但多数病人就诊时即已失去手术切除的机会。局部进展、转移性或复发病人只能接受化疗和其他综合治疗,但均无法获得令人满意的治疗效果。肿瘤靶向和免疫治疗的进展为BTC病人带来新希望,但其具体效果还有待进一步验证。

Biliary tract cancers(BTCs)include gallbladder cancer and bile duct cancer derived from bile duct epithelial cells,which are difficult to diagnose early,progress rapidly,and are in complex anatomy.Operation is the main method of BTC treatment.However,most patients have lost the opportunity for surgical resection at the time of diagnosis.Patients with local progression,metastasis or recurrence can only receive chemotherapy and other comprehensive treatment,which can get less satisfied effect.The progress of tumor targeting and immunotherapy has brought new hope to BTC patients,but its specific effect needs to be further verified.