应激性唾液标志物与牙周炎临床参数的相关性分析

Correlation between salivary stress markers and clinical parameters of periodontitis

目的:探讨应激性唾液标志物嗜铬粒蛋白A(chromogranin A,CgA)、皮质醇、α淀粉酶、β内啡肽与牙周炎临床参数龈沟出血指数(sulcus bleeding index,SBI)、牙周探诊深度(periodontal probing depth,PD)、附着丧失(attachment loss,AL)的相关性。方法:选择2017年12月-2018年12月江西省中西医结合医院口腔科收治的慢性牙周炎患者105例为牙周炎组,同期在院健康体检者105例为对照组,检测2组唾液中CgA、皮质醇、α淀粉酶、β内啡肽水平及SBI、PD、AL。采用SPSS 22.0软件包分析应激性唾液标志物与牙周炎临床参数的相关性,利用多因素Logistic回归分析明确牙周炎有关的危险因素。结果:牙周炎组唾液中CgA、皮质醇、α淀粉酶、β内啡肽水平显著高于对照组(P<0.05),牙周炎组SBI、PD、AL显著高于对照组(P<0.05),唾液中CgA、皮质醇、α淀粉酶、β内啡肽水平与SBI均呈正相关(P<0.05),唾液中CgA、皮质醇、α淀粉酶、β内啡肽水平与PD均呈正相关(P<0.05),唾液中CgA、皮质醇、α淀粉酶、β内啡肽水平与AL均呈正相关(P<0.05),CgA、皮质醇、α淀粉酶、β内啡肽是牙周炎的独立危险因素(P<0.05)。结论:应激性唾液标志物CgA、皮质醇、α淀粉酶、β内啡肽与牙周炎临床参数显著相关,提示应激性唾液标志物能在一定程度上反映牙周炎的病情进展,为牙周炎诊断和疗效监测提供有益参考。

PURPOSE:To investigate the correlation between salivary stress markers chromogranin A(CgA),cortisol,α-amylase,β-endorphin and clinical parameters of periodontitis,including sulcus bleeding index(SBI),periodontal probing depth(PD)and attachment loss(AL).METHODS:A total of 105 patients with chronic periodontitis(periodontitis group)and 105 healthy individuals(control group)visiting our hospital from December 2017 to December 2018 were selected.Indicators including CgA,cortisol,α-amylase,β-endorphin levels,SBI,PD,and AL were detected in both groups,and the correlation among them was determined by Pearson’s analysis,multivariate logistic regression was used to analyze the risk factors associated with periodontitis using SPSS 22.0 software package.RESULTS:The levels of CgA,cortisol,α-amylase andβ-endorphin in the periodontitis group were significantly higher than those in the control group(P<0.05).SBI,PD and AL in the periodontitis group were significantly higher than those in the control group(P<0.05).The levels of CgA,cortisol,α-amylase andβ-endorphin in saliva were positively correlated with SBI,PD,and AL(P<0.05).CgA,cortisol,α-amylase,andβ-endorphin were independent risk factors for periodontitis(P<0.05).CONCLUSIONS:Salivary stress markers CgA,cortisol,α-amylase,andβ-endorphin are significantly associated with clinical parameters of periodontitis,suggesting that they can reflect the progression of periodontitis,thus providing an effective reference for diagnosis and efficacy monitoring of periodontitis.