慢性阻塞性肺疾病药物治疗研究

Study on Drug Treatment of Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(COPD)是一种最常见的慢性气道疾病,其起病较为缓慢、病程较长、病情迁延难愈,在早期没有自觉症状。伴随着病情的不断发展,可出现终身不愈的慢性咳嗽,并在气道、肺血管、肺实质内出现炎症应激反应,也会并发慢性呼吸衰竭、自发性气胸、慢性肺源性心脏病等疾病,严重影响患者正常工作与生活质量。目前,临床针对COPD的治疗仍以药物为主,药物治疗的目标在于改善临床症状、提高生活质量,延缓或减弱肺功能减退,预防和治疗并发症,提高存活率,避免或减少用药副作用。因此,寻求合适的药物治疗方案来满足COPD患者的临床治疗需求对于改善患者预后具有十分重要意义。本文通过对COPD致病机制、药物治疗方案作一综述,旨在为临床治疗该疾病提供参考依据。

Chronic obstructive pulmonary disease(COPD)is one of the most common chronic airway diseases.Its onset is relatively slow,its duration is long,its condition is difficult to heal,and it has no conscious symptoms at an early stage.With the continuous development of the disease,a chronic cough that never heals,and inflammatory stress reactions in the airways,pulmonary blood vessels,and parenchyma can occur.Chronic respiratory failure,spontaneous pneumothorax,and chronic pulmonary heart disease can also occur and other diseases,which seriously affect patients'normal work and quality of life.At present,the treatment of COPD in the clinic is still mainly drugs.The goals of drug treatment are to improve clinical symptoms,improve quality of life,delay or weaken pulmonary function,prevent and treat complications,improve survival rate,and avoid or reduce side effects of medication.Therefore,it is very important to find a suitable drug treatment plan to meet the clinical treatment needs of patients with COPD.This article reviews the pathogenesis of COPD and drug treatment programs,and aims to provide a reference for clinical treatment of the disease.