摘要
目的探讨外周血红蛋白(Hb)与动脉硬化的相关性。方法采用回顾性分析方法,随机选取高血压患者419例为研究对象。采用动脉硬化测定仪检测双侧肢体的脉搏波传导速度(ba-PWV),取左右两侧较高值。根据ba-PWV值将高血压患者分为4组,S0组:动脉正常组(ba-PWV<1400 cm/s),49例(11.7%);S1组:轻度动脉硬化组(1400 cm/s<ba-PWV<1800 cm/s),190例(45.3%);S2组:中度动脉硬化组(1800 cm/s<ba-PWV<2000 cm/s),69例(16.5%);S3组:重度动脉硬化组(ba-PWV>2000 cm/s),111例(26.5%)。记录其临床资料,采用多元Logistics回归分析高血压患者动脉硬化的危险因素。结果与正常动脉组相比,不同程度动脉硬化组之间的年龄、肥胖、白蛋白、谷丙转氨酶、总胆汁酸、腺苷脱氨酶、尿素氮、肌酐、胱抑素C、低密度脂蛋白、红细胞、血红蛋白、纤维蛋白原、FT3差异有统计学意义(P<0.05)。多元Logistic回归分析结果显示,年龄是高血压患者动脉重度硬化(OR=1.094,95%CI:1.052~1.137,P<0.05)、中度动脉硬化(OR=1.081,95%CI:1.039~1.125,P<0.05)的独立危险因素。Hb是高血压患者重度动脉硬化(OR=1.025,95%CI:1.003~1.045,P<0.05)及中度动脉硬化(OR=1.035,95%CI:1.008~1.056,P<0.05)的新发独立危险因素,即Hb水平每增加1个标准差,高血压患者发生不同程度的动脉硬化风险增加1倍。结论外周血红蛋白水平与高血压动脉硬化程度呈显著相关,外周血红蛋白有望成为高血压动脉硬化新的预测指标。
Objective To investigate the relationship between peripheral blood albumin(Hb)level and the severity of arteriosclerosis in hypertensive patients.Methods This retrospective analysis was conducted among 419 randomly selected patients with hypertension.The pulse wave velocity(ba-PWV)of the bilateral limbs was measured using an arteriosclerosis tester.According to the ba-PWV value(the higher value of the two sides),the hypertensive patients were divided into 4 groups,namely normal arterial group[S0 group,ba-PWV<1400 cm/s;49 cases(11.7%)],mild arteriosclerosis group[S1 group,ba-PWV of 1400-1800 cm/s;190 cases(45.3%)],moderate arteriosclerosis group[S2 group,ba-PWV of 1800-2000 cm/s);69 cases(16.5%)],and severe arteriosclerosis group[S3 group,ba-PWV>2000 cm/s;111 cases(26.5%)].The clinical data of the patients were collected and multivariate logistic regression was used to analyze the risk factors of arteriosclerosis.Results The patients'age,obesity,albumin,alanine aminotransferase(ALT),total bile acid,adenosine deaminase,urea nitrogen,serum creatinine,cystatin C,low-density lipoprotein,red blood cells,hemoglobin(Hb),fibrinogen,and FT3 all differed significantly between S0 group and the 3 arteriosclerosis groups(P<0.05).Multivariate logistic regression analysis revealed that in hypertensive patients,age was an independent risk factor for severe arteriosclerosis(OR=1.094,95%CI:1.052-1.137,P<0.05)and moderate arteriosclerosis(OR=1.081,95%CI:1.039-1.125,P<0.05);Hb was an independent risk factor for new-onset severe arteriosclerosis(OR=1.025,95%CI:1.003-1.045,P<0.05)and moderate arteriosclerosis(OR=1.035,95%CI:1.008-1.056,P<0.05),and an increase of Hb levels by 1 standard deviation was associated with a doubled risk in hypertensive patients.Conclusion Peripheral Hb level is significantly correlated with the severity of arteriosclerosis and may serve as a new predictor for arteriosclerosis in hypertensive patients.
作者
黄建玉
马骏
郭琰
王瑶
张群辉
钟俊达
姜文才
李雁卓
徐琳
HUANG Jianyu;MA Jun;GUO Yan;WANG Yao;ZHANG Qunhui;ZHONG Junda;JIANG Wencai;LI Yanzhuo;XU Lin(Guangdong Pharmaceutical University,Guangzhou 510006,China;General Hospital of Southern Theatre Command of PLA,Guangzhou 510010,China;Jiangxi Province Hospital of Integrated Chinese and Western Medicine,Nanchang,330003,China)
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2020年第2期240-245,共6页
Journal of Southern Medical University
基金
国家自然科学基金(61771233,61976222)
国家自然科学基金国际(地区)交流与合作项目(81911530252)
广东省应用型专项资金项目(2017B010125001)
广州市科技计划项目重大专项(201704020079)
全军实验动物管理办公室(SYDW[2017]04)
后勤科研项目(CLB18J041,BLB19J005)
后勤科研拔尖项目(20QNPY082)
广东省医学科学技术研究基金(A2019161)~~