应用320排低剂量CT测量心外膜脂肪体积与冠心病的相关性分析

Correlation Between Epicardial Fat Volume and Coronary Heart Disease by 320 Row Low Dose CT

目的探讨320排低剂量CT心外膜脂肪体积(EAT)定量与冠心病的相关性。方法搜集120例疑诊冠心病、并同期行东芝320排CT冠状动脉成像(CTA)和冠状动脉造影(CAG)检查的患者为研究对象。通过CAG确定为冠心病者77例为冠心病组, CAG正常或狭窄程度<50%者43例为对照组。应用东芝320排CT测量所有患者的EAT体积;采用Gensini评分判定冠心病的严重程度;记录纳入样本的临床资料。结果冠心病组患者中年龄、尿酸、高血压、糖尿病、吸烟史、EAT与对照组比较差异有统计学意义(P<0.05)。经二元Logistic回归分析显示EAT是冠心病发生的独立危险因素。Spearman相关分析结果显示,冠心病组EAT体积与Gensini评分及病变支数之间均呈正相关(r=0.356、0.412;P=0.001,P<0.001)。结论 EAT为冠心病发生的独立危险因素,并与冠心病严重程度及病变支数存在正相关。

Objective To investigate the relationship between Epicardial adipose tissue(EAT) and coronary heart disease by 320 row low dose CT. Methods A retrospective study of 120 patients with suspected coronary heart disease who underwent Toshiba 320-slice CT coronary angiography( CTA) and coronary angiography( CAG) was performed. Seventyseven patients with coronary heart disease were identified as coronary heart disease by CAG,and 43 patients with normal or stenosis of CAG < 50% were in the control group. Toshiba 320 row CT was used to measure the EAT volume of all patients;Gensini score was used to determine the severity of coronary heart disease;the clinical data of the included samples were recorded. Results There were significant differences in age,uric acid,hypertension,diabetes,smoking history and EAT between the patients with coronary heart disease and the control group( P < 0. 05). Binary logistic regression analysis showed that EAT was an independent risk factor for coronary heart disease. Spearman correlation analysis showed that there was a positive correlation between EAT volume and Gensini score and lesion count in the coronary heart disease group( r =0. 356、0. 412;P = 0. 001,P < 0. 001). Conclusion EAT is an independent risk factor for coronary heart disease,and it is positively correlated with the severity of coronary heart disease and the number of lesions.