国际胃癌药物临床研究进展与展望

Progress and prospects of international cancer drug clinical research on gastric cancer

胃癌是常见恶性肿瘤。近年来,逐渐增多的研究者发起的临床研究为胃癌临床实践提供了宝贵的证据。本文从局部进展期胃癌的围手术期治疗入手,分别就新辅助治疗方案优化、新辅助联合治疗模式的探索、新型辅助化疗方案的研究以及放化疗在辅助治疗中地位的变化进行了综述。同时,对于晚期胃癌的治疗,综述了一线化疗方案优化进展,并对近年来新兴的免疫治疗和靶向治疗研究的曲折与进展进行总结。胃癌作为异质性极强的肿瘤,未来的研究如想取得更大的成功,靶向治疗和免疫治疗为代表的精准治疗如想有所突破,基因检测指导下的精确分子分型必定是今后的发展方向。

Gastric cancer is a common type of malignant tumor.Recently,a growing number of clinical researches initiated by investigators have provided valuable evidence for clinical practice.Here we review the perioperative treatment of locally advanced gastric cancer,and summarize the optimization of neoadjuvant treatment regimens,the exploration of new combinational treatment models and new adjuvant chemotherapy schemes,and the changes in the status of chemoradiotherapy in adjuvant therapy.At the same time,for the comprehensive treatment of advanced gastric cancer,the advances in the optimization of first-line chemotherapy regimens,emerging immunotherapy and targeted therapy are reviewed as well.Gastric cancer is a highly heterogeneous tumor.For further development of precision medicine represented by targeted therapy and immunotherapy,genetic testing-guided precise molecular subtyping will be the direction.