定志益聪颗粒治疗血管性痴呆临床观察

Clinical observation of Dingzhi Yicong granule on vascular dementia

目的:观察定志益聪颗粒治疗血管性痴呆的疗效。方法:采用随机对照的方法,将156例符合诊断标准的患者按随机数字表法分为两组各78例。治疗组采用定志益聪颗粒治疗,对照组采用奥拉西坦胶囊治疗,两组均治疗3个月;以患者简易精神状态检查(MMSE)评分、阿尔茨海默病评估量表-认知部分(ADAS-cog)、临床痴呆评定量表(CDR)评分进行评定,观察并比较两组治疗3个月的疗效,治疗后6个月观察两组各评分情况。结果:治疗组疗效为83.3%,优于对照组65.38%,两组疗效比较差异有统计学意义(P<0.05)。结论:定志益聪颗粒可以有效改善轻中度血管性痴呆患者的认知功能,改善患者的生存质量。

Objective:To observe the clinical effect of Dingzhi Yicong granule on vascular dementia.Methods:The diagnostic criteria-met patients were randomly divided into two groups by randomized control method.The observation group was treated with Dingzhi Yicong granule,while the control group was treated with oxiracetam capsule,the course of treatment was 3 months.Mini mental-state examination(MMSE)score,Alzheimer’s disease assessment scale-cognitive part(ADAS-cog)score and cilnical dementia rating scale(CDR)score were observed,so as to assess the patients.The efficacy of treatment for 3 months was observed.Results:The efficacy of observation group was 83.33%,better than that of control group of 65.38%.Compared two groups,(P﹤0.01).Conclusion:Dingzhi Yicong granule can effectively improve the cognitive function of patients with mild or moderate vascular dementia and the patients’quality of life.