季节性流行性感冒疫苗对儿童保护效果的meta分析

Meta-analysis on the protective efficacy of seasonal influenza vaccine among children

目的本文拟采用meta分析的方法定量综合现有研究季节性流行性感冒疫苗对儿童保护效果的研究结果,为提高儿童接种流感疫苗有效性和计划免疫决策提供依据。方法计算机检索PubMed、Embase、Cochrane图书馆、中国知网以及万方数据库,检索时限截至2018年12月。采用Stata 12.0软件进行meta分析。结果最终纳入17个病例对照研究,共18组数据。Meta分析结果显示:全程接种季节性流感疫苗预防流感效果合并效应值OR为0.47,95%CI为0.43~0.51;8岁以下未完成季节性流感疫苗全程接种者(仅接种1剂)预防流感效果合并效应值OR为0.61,95%CI为0.51~0.74。结论儿童全程或部分接种季节性流感疫苗可减少季节性流感的发病,全程接种效果优于部分接种。

Objective To perform a meta-analysis on the current existing studies related to protective efficacy of seasonal influenza vaccine among children so as to provide a basis for improving the effectiveness of influenza vaccination among children and developing strategies for planned immunization.Methods We electronically searched the databases of PubMed,Embase,the Cochrane Library,CNKI and WanFang databases.The research deadline was December,2018.Stata 12.0 software was used for meta-analysis.Results A total of 17 case-control studies were finally included in this meta-analysis.And the results showed that the odds ratio(OR)and 95%confidence interval(95%CI)of full-course vaccination of seasonal influenza vaccine were 0.47 and 0.43-0.51,respectively.The OR and 95%CI of partial vaccination(only receiving one dose of vaccine)among children aged below 8 years were 0.61 and 0.51-0.74,respectively.Conclusions Full-course and partial vaccination of seasonal influenza vaccine in children can reduce the incidence of seasonal influenza.The effectiveness of full-course vaccination is superior to that of partial vaccination.