妇女孕前和孕期维生素D水平及影响因素

Study on the levels and risk factors of Vitamin D from preconception to pregnancy

目的了解上海市嘉定区妇女孕前、孕中期和孕晚期体内维生素D(Vitamin D,VD)水平的现状,探讨孕中期和孕晚期VD水平的影响因素。方法选取2016年9月至2018年12月在上海市嘉定区妇幼保健院参加孕前检查并随访到分娩的94名妇女为研究对象,采用化学发光法检测孕前、中期和晚期血清中的VD水平,共检测282份血清。结果94名妇女的孕前、孕中期和晚期的VD缺乏率分别为:40.4%、57.4%和48.9%。混合线性模型结果显示,近1年内有过染发/烫发的妇女孕期血清VD水平较低(P<0.05),孕期经常喝牛奶和吃深海鱼的妇女在孕期VD水平较高(P<0.05)。结论上海嘉定区妇女孕前和孕期VD缺乏普遍,应该重视在孕前和孕期VD的补充。

Objective To investigate the levels of serum Vitamin D(VD)from preconception to pregnancy in Jiading district of Shanghai,and explore the risk factors of VD concentration deficiency in the second and third trimester of pregnancy.Methods A total of 94 women who planned to have antenatal care and delivery in Maternal and Child Health Hospital of Jiading district of Shanghai from September 2016 to December 2018 were recruited as the study participants.Chemiluminescent immunoassay(CLIA)was used to examine the concentration of women’s serum VD from preconception to pregnancy.A total of 282 serum samples were detected.Results The prevalence of VD deficiency among 94 women from preconception to pregnancy were 40.4%,57.4%and 48.9%respectively.Results of the mixed linear model showed that women who had dyed or permed hair within the past 1 year had significantly lower serum VD levels during pregnancy(P<0.05),and women who often drank milk and ate deep-sea fish during pregnancy had higher VD levels during pregnancy(P<0.05).Conclusions VD deficiency was common among women in Jiading district of Shanghai,and it should be emphasized to supplement VD before and during pregnancy.