皮质-基底神经节-丘脑网络的振荡动力学分析

ANALYSES OF OSCILLATION DYNAMICS IN CORTEX-BASAL GANGLIA-THALAMUS NETWORK

探究大脑基底神经节中丘脑底核和苍白球神经核团振荡动力学的起源对理解帕金森病的发病机理起到重要作用。本文建立了较为完整的关于帕金森病的神经网络模型,该模型含有兴奋和抑制神经元的大脑皮质、由纹状体、丘脑底核、苍白球内侧和外侧构成的基底神经节以及丘脑。首先,通过对模型进行数值模拟,所得的动力学结果与丘脑底核和苍白球振荡相关的生物实验结果一致。其次,探讨了与丘脑底核和苍白球神经核团相关的突触连接强度对他们振荡动力学的影响。我们的结果显示,丘脑底核同时受到纹状体较强的促进作用和苍白球外侧较弱的抑制作用时它的振荡消失。而当苍白球同时受到丘脑底核较强的促进作用和纹状体对它的抑制作用时,苍白球的振荡增强。希望本文的研究结果对帕金森病的治疗有一定的指导作用。

Exploring the origin of oscillation dynamics of subthalamic nucleus and globus pallidus in basal ganglia plays an important role in understanding the pathogenesis of Parkinson^s disease.In this paper,a more complete neural network model for Parkinson^s disease is established.The model contains the cortex with excitatory and inhibitory neurons,basal ganglia composed of striatum,subthalamic nucleus,external and internal segment of globus pallidus and thalamus.First,the dynamic results obtained through numerical simulation of the model are consistent with the biological experimental results related to the oscillations in the subthalamic nucleus and the globus pallidus.Secondly,the effects of synaptic connection weights associated with subthalamic nucleus and globus pallidus on their oscillation dynamics were discussed.Our results show that the oscillation in the subthalamic nucleus will disappear for stronger excitatory connection weights from the striatum and weaker inhibitory connection weights from external segment of globus pallidus.Also,oscillation in the globus pallidus will appear for both stronger excitatory and inhibitory connection weights from the subthalamic nucleus the striatum,respectively.lt is hoped that the results of this study will play a guiding role in the treatment of Parkinson's disease.