中医药治疗阿尔茨海默病作用机制研究进展

Research Progress in The Mechanism of Traditional Chinese Medicine in the Treatment of Alzheimer’s Disease

阿尔茨海默病(AD)是以tau蛋白的过度磷酸化和β-淀粉样蛋白沉淀形成的老年斑为主要病理特征的中枢神经系统退行性疾病。其常见的临床症状为记忆功能减退、人格改变、认知功能障碍。目前,还不清楚AD的发病机制,而真正能阻止疾病进展或彻底治愈阿尔茨海默病的药物也尚未问世。近年来,许多研究表明中医药可通过拮抗Aβ的产生、抑制tau蛋白的高度磷酸化、减少神经元凋亡,防止炎症反应和氧化应激,有效地控制AD的发展。文章通过对近年来中医药治疗AD的临床资料、实验资料进行了总结,探讨中医药治疗AD的机制,为今后中医药治疗AD的研究提供理论依据。

Alzheimer’s disease(AD)is a degenerative disease of the central nervous system characterized by senile plaque formed by tau protein over-phosphorylation andβ-amyloid protein precipitation.The common clinical symptoms are memory impairment,personality change and cognitive impairment.At present,the pathogenesis of AD is not clear,and drugs that can really prevent the progression of the disease or cure Alzheimer’s disease have not been published.In recent years,many studies have shown that TCM can effectively control the development of AD by antagonizing the production of Aβ,inhibiting the high phosphorylation of tau protein,reducing neuronal apoptosis,preventing inflammatory reaction and oxidative stress.This paper summarizes the clinical and experimental data of AD treated by traditional Chinese medicine in recent years,and explores the mechanism of Chinese medicine treating AD,so as to provide theoretical basis for the research of Chinese medicine treating AD in the future.