宫颈癌患者新辅助化疗前后TK1、ID-1水平变化与疗效的关系

Relationship between the changes of TK1 and ID-1 levels and curative effect in cervical cancer patients before and after neoadjuvant chemotherapy

目的探讨宫颈癌患者新辅助化疗前后胸苷激酶1(TK1)、细胞分化抑制因子-1(ID-1)水平变化与化疗疗效的关系。方法选取行新辅助化疗的宫颈癌患者200例,检测化疗前、后的血清TK1、ID-1水平。采用受试者工作特征(ROC)曲线评估各项指标判断宫颈癌化疗有效性的效能。结果 200例宫颈癌患者的化疗有效率为56.00%。化疗无效组化疗后血清TK1、ID-1水平明显高于化疗前(P<0.05)。化疗有效组化疗后血清TK1、ID-1水平明显低于化疗前(P<0.05)。化疗有效组化疗后血清TK1、ID-1水平明显低于化疗无效组(P<0.001),且化疗后TK1、ID-1水平下降比明显高于化疗无效组(P<0.001)。ROC曲线分析结果显示,TK1下降比判断宫颈癌化疗有效的最佳临界值为>24.0%,曲线下面积(AUC)为0.756,ID-1下降比判断宫颈癌化疗有效的临界值为>36.0%,AUC为0.738,二者联合检测的AUC为0.902。结论 TK1、ID-1可作为评估宫颈癌新辅助化疗疗效的指标,二者联合检测的评价效能更高。

Objective To investigate the relationship between the changes of thymidine kinase-1(TK1) and inhibitor-1 of cell differentiation(ID-1) levels and curative effect in cervical cancer patients before and after neoadjuvant chemotherapy. Methods A total of 200 patients with cervical cancer treated with neoadjuvant chemotherapy were enrolled,and serum TK1 and ID-1 levels were determined before and after neoadjuvant chemotherapy. The efficiency of each index for cervical cancer was evaluated by receiver operating characteristic(ROC) curve. Results The effective rate of chemotherapy in 200 patients with cervical cancer was 56.00%. The TK1 and ID-1 levels in patients with ineffective chemotherapy after chemotherapy were higher than those before chemotherapy(P<0.05). The TK1 and ID-1 levels in patients with effective chemotherapy after chemotherapy were lower than those before chemotherapy(P<0.05). The TK1 and ID-1 levels in patients with effective chemotherapy after chemotherapy were lower than those in patients with ineffective chemotherapy(P<0.001),and serum TK1 and ID-1 decline ratios in patients with effective chemotherapy were higher than those in patients with ineffective chemotherapy(P<0.001). ROC curve analysis showed that the optimal cut-off value of TK1 decline ratio for judging the effectiveness of chemotherapy for cervical cancer was >24.0%,and the area under curve(AUC) was 0.756. The optimal cut-off value of ID-1 decline ratio for judging the effectiveness of chemotherapy for cervical cancer was >36.0%,the AUC was 0.738,and the AUC of TK1 combined with ID-1 was 0.902. Conclusions TK1 and ID-1 can be used as indexes for evaluating the efficiency of chemotherapy,and the determination of TK1 combined with ID-1 is effective.