阿奇霉素联合清热止咳糖浆在小儿肺炎中的临床效果及对气道炎症因子的影响研究

Clinical Effect of Azithromycin Combined with Qingre Cough Syrup in Children with Pneumonia and Its Effect on Airway Inflammatory Factors

目的:探讨阿奇霉素联合清热止咳糖浆在小儿肺炎患者中的临床效果及对气道炎症因子的影响。方法:选择2018年5月-2019年3月笔者所在医院小儿肺炎患者182例作为研究对象,将其随机分为对照组(n=91)和观察组(n=91)。对照组给予阿奇霉素治疗,观察组在对照组基础上联合清热止咳糖浆治疗。比较两组症状消失时间、气道炎症因子水平及药物安全性。结果:观察组治疗后咳嗽消失时间、发热消失时间、肺部啰音消失时间、X线检查正常时间及住院时间均优于对照组,差异有统计学意义(P<0.05)。观察组治疗后14 d炎症因子IL-2、IFN-γ水平高于对照组,IL-4、IL-6水平低于对照组,差异均有统计学意义(P<0.05)。两组治疗过程中肝肾异常、消化道出血、便秘腹泻、皮疹过敏发生率比较差异无统计学意义(P>0.05)。结论:阿奇霉素联合清热止咳糖浆用于小儿肺炎中能缩短症状消失时间,有助于降低气道炎症因子水平,未增加不良反应发生率,值得推广应用。

Objective: To investigate the clinical effect of Azithromycin combined with Qingre Cough Syrup in children with pneumonia and its effect on airway inflammatory factors. Method: A total of 182 children with pneumonia in our hospital from May 2018 to March 2019 were selected as the study subjects and randomly divided into the control group(n=91) and the observation group(n=91). The control group was treated with Azithromycin. The observation group was treated with Qingre Cough Syrup on the basis of the control group. The time of symptom disappearance, level of airway inflammatory factors and drug safety were compared between the two groups. Result: After treatment, the time of disappearance of cough, time of disappearance of fever, time of disappearance of lung rales, time of X-ray examination and hospital stay in the observation group were all better than the control group, the differences were statistically significant(P<0.05). After 14 d of treatment, the levels of inflammatory factors IL-2 and IFN-γ in the observation group were higher than those in the control group, while the levels of IL-4 and IL-6 were lower than those in the control group, the differences were statistically significant(P<0.05). There were no significant differences in the incidence of liver and kidney abnormalities, gastrointestinal bleeding, constipation and diarrhea, and rash and allergy between the two groups during the treatment(P>0.05). Conclusion: Azithromycin combined with Qingre Cough Syrup in children with pneumonia can shorten the time of symptom disappearance, help to reduce the level of airway inflammatory factors, without increase the incidence of adverse reactions. It is worthy of popularization and application.