盐酸羟考酮控释片治疗中重度癌性疼痛的效果

Effect of Oxycodone Hydrochloride Controlled-release Tablets in the Treatment of Moderate to Severe Cancer Pain

目的:探讨盐酸羟考酮控释片治疗中重度癌性疼痛的效果。方法:选取笔者所在医院2017年2月-2019年5月收治的癌症患者126例,按随机双盲法分为参照组和研究组,各63例。参照组给予曲马多镇痛治疗,研究组给予盐酸羟考酮控释片镇痛治疗,对比两组治疗前后疼痛数字评分法(NRS)评分及不良反应情况。结果:治疗前两组NRS评分比较,差异无统计学意义(P>0.05);两组治疗后NRS评分均低于治疗前,差异均有统计学意义(P<0.05);研究组治疗后NRS评分低于参照组,差异有统计学意义(P<0.05)。研究组不良反应发生率为9.52%,低于参照组的26.98%,差异有统计学意义(P<0.05)。结论:盐酸羟考酮控释片治疗中重度癌性疼痛的效果显著,临床推广价值高。

Objective: To investigate the effect of Oxycodone Hydrochloride Controlled-release Tablets in the treatment of moderate to severe cancer pain. Method: A total of 126 cancer patients admitted to our hospital from February 2017 to May 2019 were enrolled. According to the randomized double-blind method, the patients were divided into the reference group and the study group, 63 cases in each group. The reference group was treated with Tramadol analgesia treatment, and the study group was treated with Oxycodone Hydrochloride Controlled-release Tablets analgesia treatment, and the numerical rating scale(NRS) scores before and after treatment and adverse reactions were compared between the two groups. Result: Before treatment, NRS scores were compared between the two groups, and the difference was not statistically significant(P>0.05). After treatment, the NRS scores of the two groups were lower than those before treatment, and the differences were significant(P<0.05). After treatment, the NRS score of the study group was lower than that of the reference group, and the difference was significant(P<0.05). The incidence of adverse reactions in the study group was 9.52%, which was lower than 26.98% of the reference group, and the difference was significant(P<0.05). Conclusion: Oxycodone Hydrochloride Controlled-release Tablets is effective in the treatment of moderate to severe cancer pain, and has a high clinical promotion value.