CYP2D6基因多态性与老年抑郁症及其疗效的关联研究

Correlation between CYP2D6 gene polymorphism and senile depression and its efficacy

目的研究CYP2D6基因多态性与老年抑郁症及其疗效的关联性。方法选取抑郁症患者(研究组)和同院体检健康者(对照组)各100例,提取DNA并采用聚合酶链反应(PCR)方法对CYP2D6基因进行扩增。结果两组CYP2D62850C>T、100C>T、1758G>A基因型及等位基因频率比较,差异无统计学意义(P>0.05)。研究组不同基因型患者的HAMD总分及各因子分比较,差异无统计学意义(P>0.05)。CYP2D62850C>T、100C>T、1758G>A分组中,有效组和无效组等位基因频率比较,差异存在统计学意义(P<0.05);有不良反应组和无不良反应组等位基因频率比较,差异存在统计学意义(P<0.05)。Logistic回归分析显示,CYP2D6基因型和等位基因频率与疗效及不良反应具有相关性(P<0.05)。结论CYP2D6基因多态性与老年抑郁症的发生不相关,但与老年抑郁症的疗效及不良反应具有相关性。

Objective To explore the correlation between CYP2D6 gene polymorphism and senile depression and its efficacy.MethodsA total of 100 patients with senile depression(study group)and 100 healthy controls(control group)were selected and their DNA were extracted and amplified by polymerase chain reaction(PCR).ResultsThere was no significant difference for CYP2D6(2850C>T,100C>T,and 1758G>A)genotypes and allele frequencies between two groups(P>0.05).There was no significant difference in the total score and all factor scores of HAMD among patients with different genotypes in study group(P>0.05).There existed significant differences in allele frequencies between effective group and ineffective group as well as between adverse reaction group and non-adverse reaction group in CYP2D62850C>T,100C>T and 1758G>A groups.Logistic regression analysis showed that CYP2D6 genotypes and allele frequencies were correlated with efficacy and adverse reactions(P<0.05).ConclusionCYP2D6 gene polymorphism is not related to the occurrence of senile depression,but is related to the efficacy and adverse reactions of depression in the elderly.