终末期肾病患者认知障碍的神经影像学研究进展

Neuroimaging advances in the studies on cognitive dysfunction in patients with end-stage renal disease

终末期肾病(end-stage renal disease,ESRD)是慢性肾脏病发展终末期阶段最严重的转归,患者需要透析或者肾移植才能维持生命。根据流行病学调查,ESRD患者普遍存在认知功能障碍,这是影响患者生活质量的关键问题之一。本文以ESRD患者为研究载体,基于磁共振神经影像技术阐述了ESRD、大脑结构和功能以及认知功能之间的潜在关系,并指出基于影像学标记预测认知转归是需要重点解决的问题。

End-stage renal disease(ESRD)is the serious outcome of chronic kidney disease.ESRD patients need dialysis or kidney transplantation to sustain life.According to epidemiological investigations,ESRD patients generally have cognitive dysfunction,which is one of the key problems affecting patients'quality of life.In this paper,the potential relationship among ESRD,brain structure and function,and cognitive function is described based on magnetic resonance imaging technology in ESRD patients.This paper points out that the key problem to be solved is to predict cognitive outcome based on imaging markers.