摘要
为研究华中五味子(Schisandra sphenanthera Rehd.et Wils.)的化学成分以及活性,利用正相硅胶色谱、反相硅胶色谱、半制备HPLC等方法从华中五味子(Schisandra sphenanthera Rehd.et Wils.)藤茎中分离、纯化得到7个化合物并通过波谱数据鉴定了其结构。经鉴定分别为6′′-O-对羟基苯甲酰红景天苷(1)、nectandrin B(2)、7-(3,4-dimethoxyphenyl)-7′(4′-hydroxy-3′-methoxyphenyl)-8,8′(dimethylbutyl)acetate(3)、henricine B(4)、(8 R,8′R)-3,4-dimethoxy-3′,4′-methylenedioxy-7,7′-dioxo-8,8′-neolignan(5)、secoisolariciresinol(6)、calceolarioside B(7)。其中化合物1为新化合物,化合物1、6、7具有较好的NO释放的抑制作用。
To study the chemical constituents and activities of Schisandra sphenanthera Rehd.et Wils..The constituents were isolated and purified with normal phase silica gel chromatography,reversed phase silica gel chromatography and semi-preparative HPLC methods from the bark of dried stems of S.sphenanthera,which were identified by spectral data.They were identified as 6′′-O-p-hydroxybenzoyl salidroside(1),nectandrin B(2),7-(3,4-dimethoxyphenyl)-7′(4′-hydroxy-3′-methoxyphenyl)-8,8′(dimethylbutyl)acetate(3),henricine B(4),(8 R,8′R)-3,4-dimethoxy-3′,4′-methylenedioxy-7,7′-dioxo-8,8′-neolignan(5),secoisolariciresinol(6),calceolarioside B(7).Compound 1 is a new compound.Compounds 1,6 and 7 have good inhibitory effects on NO release.
作者
季嘉诚
邱峰
雷新响
JI Jia-cheng;QIU Feng;LEI Xin-xiang(School of Pharmacy,South-Central University for Nationalities,Wuhan 430074,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2020年第1期70-74,共5页
Natural Product Research and Development
基金
中南民族大学科研启动基金(YZZ16001)
关键词
华中五味子
糖苷类
木脂素
结构鉴定
活性研究
Schisandra sphenanthera Rehd.et Wils.
glycosides
lignans
structural identification
activity study